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The diversity of sex steroid action : the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer

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Lam, E. W. -F., Shah, K. and Brosens, Jan J. (2011) The diversity of sex steroid action : the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer. Journal of Endocrinology, 212 (1). pp. 13-25. doi:10.1530/JOE-10-0480 ISSN 0022-0795.

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Official URL: http://dx.doi.org/10.1530/JOE-10-0480

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Abstract

The rise and fall in ovarian estrogen and progesterone production orchestrates a series of events that are indispensable for reproduction, including ovulation, implantation, decidualisation and menstruation. In the uterus, these events involve extensive tissue remodelling, characterised by waves of endometrial cell proliferation, differentiation, recruitment of inflammatory cells, apoptosis, tissue breakdown, menstruation and regeneration. The ability of ovarian hormones to trigger such diverse physiological responses is foremost dependent upon interaction of activated steroid receptors with specific transcription factors, such FOXO proteins, involved in cell fate decisions. Furthermore, microRNAs, small non-coding RNAs that function as posttranscriptional regulators of gene expression, have emerged as a major regulator system of steroid hormone responses in the female reproductive tract. Consequently, increasing evidence shows that deregulated uterine microRNA expression underpins a spectrum of common reproductive disorders, ranging from implantation failure to endometriosis. Furthermore, by targeting FOXO transcription factors and other key regulators of tissue homeostasis, oncogenic endometrial microRNAs promote tumorigenesis and cancer progression.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Journal of Endocrinology
Publisher: Society for Endocrinology
ISSN: 0022-0795
Official Date: 2011
Dates:
DateEvent
2011UNSPECIFIED
Volume: 212
Number: 1
Page Range: pp. 13-25
DOI: 10.1530/JOE-10-0480
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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