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Intranasal immunisation with recombinant adenovirus vaccines protects against a lethal 2 challenge with pneumonia virus of mice

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Maunder, Helen E., Taylor, Geraldine, Leppard, Keith and Easton, A. J. (Andrew J.) (2015) Intranasal immunisation with recombinant adenovirus vaccines protects against a lethal 2 challenge with pneumonia virus of mice. Vaccine, 33 (48). pp. 6641-6649. doi:10.1016/j.vaccine.2015.10.105

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Official URL: http://dx.doi.org/10.1016/j.vaccine.2015.10.105

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Abstract

Pneumonia virus of mice (PVM) infection of BALB/c mice induces bronchiolitis leading to a fatal pneumonia in a dose-dependent manner, closely paralleling the development of severe disease during human respiratory syncytial virus infection in man, and is thus a recognised model in which to study the pathogenesis of pneumoviruses. This model system was used to investigate delivery of the internal structural proteins of PVM as a potential vaccination strategy to protect against pneumovirus disease. Replication-deficient recombinant human adenovirus serotype 5 (rAd5) vectors were constructed that expressed the M or N gene of PVM pathogenic strain J3666. Intranasal delivery of these rAd5 vectors gave protection against a lethal challenge dose of PVM in three different mouse strains, and protection lasted for at least 20 weeks post-immunisation. Whilst the PVM-specific antibody response isuch animals was weak and inconsistent, rAd5N primed a strong PVM-specific CD8+ T cell response and, to a lesser extent, a CD4+ T cell response. These findings suggest that protection induced by rAd5N was mediated by T-cells rather than serum antibody.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Viral pneumonia -- Vaccination, Vaccines, Intranasal medication, Adenoviruses
Journal or Publication Title: Vaccine
Publisher: Elsevier Ltd.
ISSN: 0264-410X
Official Date: 27 November 2015
Dates:
DateEvent
27 November 2015Published
1 November 2015Available
22 October 2015Accepted
29 August 2015Submitted
Volume: 33
Number: 48
Page Range: pp. 6641-6649
DOI: 10.1016/j.vaccine.2015.10.105
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Medical Research Council (Great Britain) (MRC)
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