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In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer–peptide conjugates
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Collins, Jennifer, Tanaka, Joji, Wilson, Paul, Kempe, Kristian, Davis, Thomas P., McIntosh, Michelle P., Whittaker, Michael R. and Haddleton, David M. (2015) In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer–peptide conjugates. Bioconjugate Chemistry, 26 (4). pp. 633-638. doi:10.1021/bc5006202
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Official URL: http://dx.doi.org/10.1021/bc5006202
Abstract
The in situ one-pot synthesis of peptide–polymer bioconjugates is reported. Conjugation occurs efficiently without the need for purification of dithiophenol maleimide functionalized polymer as a disulfide bridging agent for the therapeutic oxytocin. Conjugation of polymers was demonstrated to be reversible and to significantly improve the solution stability of oxytocin.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry | ||||||
| Divisions: | Faculty of Science > Chemistry | ||||||
| Library of Congress Subject Headings (LCSH): | Polypeptides | ||||||
| Journal or Publication Title: | Bioconjugate Chemistry | ||||||
| Publisher: | American Chemical Society | ||||||
| ISSN: | 1043-1802 | ||||||
| Official Date: | 5 March 2015 | ||||||
| Dates: |
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| Volume: | 26 | ||||||
| Number: | 4 | ||||||
| Number of Pages: | 6 | ||||||
| Page Range: | pp. 633-638 | ||||||
| DOI: | 10.1021/bc5006202 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Funder: | Royal Society (Great Britain), Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Engineering and Physical Sciences Research Council (EPSRC), Australian Research Council (ARC) | ||||||
| Grant number: | CE140100036 (ARC) |
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