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In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer–peptide conjugates

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Collins, Jennifer, Tanaka, Joji, Wilson, Paul, Kempe, Kristian, Davis, Thomas P., McIntosh, Michelle P., Whittaker, Michael R. and Haddleton, David M. (2015) In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer–peptide conjugates. Bioconjugate Chemistry, 26 (4). pp. 633-638. doi:10.1021/bc5006202

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Official URL: http://dx.doi.org/10.1021/bc5006202

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Abstract

The in situ one-pot synthesis of peptide–polymer bioconjugates is reported. Conjugation occurs efficiently without the need for purification of dithiophenol maleimide functionalized polymer as a disulfide bridging agent for the therapeutic oxytocin. Conjugation of polymers was demonstrated to be reversible and to significantly improve the solution stability of oxytocin.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH): Polypeptides
Journal or Publication Title: Bioconjugate Chemistry
Publisher: American Chemical Society
ISSN: 1043-1802
Official Date: 5 March 2015
Dates:
DateEvent
5 March 2015Published
29 December 2014Submitted
Date of first compliant deposit: 31 December 2015
Volume: 26
Number: 4
Number of Pages: 6
Page Range: pp. 633-638
DOI: 10.1021/bc5006202
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Royal Society (Great Britain), Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Engineering and Physical Sciences Research Council (EPSRC), Australian Research Council (ARC)
Grant number: CE140100036 (ARC)

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