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Conjugation of polymers to proteins through an inhibitor-derived peptide : taking up the inhibitor “berth”
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Tang, Zengchao, Li, Dan, Luan, Yafei, Zhu, Lijuan, Du, Hui, Tao, Yunwen, Wang, Yanwei, Haddleton, David M. and Chen, Hong (2015) Conjugation of polymers to proteins through an inhibitor-derived peptide : taking up the inhibitor “berth”. Chemical Communications, 51 (50). pp. 10099-10102. doi:10.1039/c5cc02659h ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/C5CC02659H
Abstract
A hexapeptide derived from an enzyme inhibitor was used as an affinity ligand for the conjugation of a hydrophilic polymer to the enzyme. The peptide targeted the polymer to the “berth” of the inhibitor in the enzyme, affording the enzyme resistance to the inhibitor without affecting the enzymatic activity.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Journal or Publication Title: | Chemical Communications | ||||||||
Publisher: | Royal Society of Chemistry | ||||||||
ISSN: | 1359-7345 | ||||||||
Official Date: | 25 June 2015 | ||||||||
Dates: |
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Volume: | 51 | ||||||||
Number: | 50 | ||||||||
Page Range: | pp. 10099-10102 | ||||||||
DOI: | 10.1039/c5cc02659h | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Adapted As: |
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