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Twenty years of bacterial genome sequencing
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Loman, Nicholas J. and Pallen, Mark J. (2015) Twenty years of bacterial genome sequencing. Nature Reviews Microbiology . doi:10.1038/nrmicro3565
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Official URL: http://dx.doi.org/10.1038/nrmicro3565
Abstract
Twenty years ago, the publication of the first bacterial genome sequence, from Haemophilus influenzae, shook the world of bacteriology. In this Timeline, we review the first two decades of bacterial genome sequencing, which have been marked by three revolutions: whole-genome shotgun sequencing, high-throughput sequencing and single-molecule long-read sequencing. We summarize the social history of sequencing and its impact on our understanding of the biology, diversity and evolution of bacteria, while also highlighting spin-offs and translational impact in the clinic. We look forward to a 'sequencing singularity', where sequencing becomes the method of choice for as-yet unthinkable applications in bacteriology and beyond.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Nature Reviews Microbiology | ||||
| Publisher: | Nature Publishing Group | ||||
| ISSN: | 1740-1526 | ||||
| Official Date: | 9 November 2015 | ||||
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| DOI: | 10.1038/nrmicro3565 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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