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Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium
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(2015) Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium. Frontiers in Microbiology, 6 . pp. 1-7. 1036. doi:10.3389/fmicb.2015.01036 ISSN 1664-302X.
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Official URL: http://dx.doi.org/10.3389/fmicb.2015.01036
Abstract
The International Pseudomonas aeruginosa Consortium is sequencing over 1000 genomes and building an analysis pipeline for the study of Pseudomonas genome evolution, antibiotic resistance and virulence genes. Metadata, including genomic and phenotypic data for each isolate of the collection, are available through the International Pseudomonas Consortium Database (http://ipcd.ibis.ulaval.ca/). Here, we present our strategy and the results that emerged from the analysis of the first 389 genomes. With as yet unmatched resolution, our results confirm that P. aeruginosa strains can be divided into three major groups that are further divided into subgroups, some not previously reported in the literature. We also provide the first snapshot of P. aeruginosa strain diversity with respect to antibiotic resistance. Our approach will allow us to draw potential links between environmental strains and those implicated in human and animal infections, understand how patients become infected and how the infection evolves over time as well as identify prognostic markers for better evidence-based decisions on patient care.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RC Internal medicine | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Pseudomonas aeruginosa, Genomics, Cystic fibrosis, Diagnostic microbiology | ||||||||
| Journal or Publication Title: | Frontiers in Microbiology | ||||||||
| Publisher: | Frontiers Research Foundation | ||||||||
| ISSN: | 1664-302X | ||||||||
| Official Date: | 29 September 2015 | ||||||||
| Dates: |
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| Volume: | 6 | ||||||||
| Number of Pages: | 7 | ||||||||
| Page Range: | pp. 1-7 | ||||||||
| Article Number: | 1036 | ||||||||
| DOI: | 10.3389/fmicb.2015.01036 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 31 December 2015 | ||||||||
| Date of first compliant Open Access: | 31 December 2015 | ||||||||
| Funder: | Canadian Cystic Fibrosis Foundation, Canadian Institutes of Health Research (CIHR), Cystic Fibrosis Trust, National Institutes of Health (U.S.) (NIH), Queensland Health, National Health and Medical Research Council (Australia) (NHMRC) , Prince Charles Hospital Foundation, Marie Curie Fellowship Association (MCFA), CureKids, Cystic Fibrosis Association of New Zealand, Cisco systems, Inc, Natural Sciences and Engineering Research Council of Canada (NSERC), Canada Research Chairs (CRC) | ||||||||
| Grant number: | P30 DK089507 (NIH), #455919 (NHMRC), ERS-EU RESPIRE2 (MCFA), MOP-142466 (CIHR) |
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