Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Vaccine induced herd immunity for control of respiratory syncytial virus disease in a low-income country setting

Tools
- Tools
+ Tools

Kinyanjui, Timothy M., House, Thomas A., Kiti, Moses C., Cane, Patricia, Nokes, D. James and Medley, Graham (2015) Vaccine induced herd immunity for control of respiratory syncytial virus disease in a low-income country setting. PLoS One, 10 (9). pp. 1-16. e0138018. doi:10.1371/journal.pone.0138018

[img]
Preview
PDF
WRAP_journal.pone.0138018.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (2121Kb) | Preview
Official URL: http://dx.doi.org/10.1371/journal.pone.0138018

Request Changes to record.

Abstract

Background: Respiratory syncytial virus (RSV) is globally ubiquitous, and infection during the first six months of life is a major risk for severe disease and hospital admission; consequently RSV is the most important viral cause of respiratory morbidity and mortality in young children. Development of vaccines for young infants is complicated by the presence of maternal antibodies and immunological immaturity, but vaccines targeted at older children avoid these problems. Vaccine development for young infants has been unsuccessful, but this is not the case for older children (> 6m). Would vaccinating older children have a significant public health impact? We developed a mathematical model to explore the benefits of a vaccine against RSV.

Methods and Findings: We have used a deterministic age structured model capturing the key epidemiological characteristics of RSV and performed a statistical maximum-likelihood fit to age-specific hospitalization data from a developing country setting. To explore the effects of vaccination under different mixing assumptions, we included two versions of contact matrices: one from a social contact diary study, and the second a synthesised construction based on demographic data. Vaccination is assumed to elicit an immune response equivalent to primary infection. Our results show that immunisation of young children (5–10m) is likely to be a highly effective method of protection of infants (<6m) against hospitalisation. The majority benefit is derived from indirect protection (herd immunity). A full sensitivity and uncertainty analysis using Latin Hypercube Sampling of the parameter space shows that our results are robust to model structure and model parameters.

Conclusions: This result suggests that vaccinating older infants and children against RSV can have a major public health benefit.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science > Life Sciences (2010- )
Faculty of Science > Mathematics
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Respiratory syncytial virus
Journal or Publication Title: PLoS One
Publisher: Public Library of Science
ISSN: 1932-6203
Official Date: 21 September 2015
Dates:
DateEvent
21 September 2015Published
24 August 2015Accepted
1 May 2015Submitted
Date of first compliant deposit: 31 December 2015
Volume: 10
Number: 9
Number of Pages: 16
Page Range: pp. 1-16
Article Number: e0138018
DOI: 10.1371/journal.pone.0138018
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Wellcome Trust (London, England)
Grant number: 077092 (WT), 084633 (WT), 098556 (WT)

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us