The Library
SMN, Gemin2 and Gemin3 associate with β-actin mRNA in the cytoplasm of neuronal cells in vitro
Tools
Tools
Tools
Todd, Adrian G., Morse, Robert, Shaw, Debra J., McGinley, Samuel, Stebbings, Howard and Young, Philip J. (2010) SMN, Gemin2 and Gemin3 associate with β-actin mRNA in the cytoplasm of neuronal cells in vitro. Journal of Molecular Biology, 401 (5). pp. 681-689. doi:10.1016/j.jmb.2010.06.058 ISSN 0022-2836.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.jmb.2010.06.058
Abstract
Childhood spinal muscular atrophy is caused by a reduced expression of the survival motor neuron (SMN) protein. SMN has been implicated in the axonal transport of β-actin mRNA in both primary and transformed neuronal cell lines, and loss of this function could account, at least in part, for spinal muscular atrophy onset and pathological specificity. Here we have utilised a targeted screen to identify mRNA associated with SMN, Gemin2 and Gemin3 in the cytoplasm of a human neuroblastoma cell line, SHSY5Y. Importantly, we have provided the first direct evidence that β-actin mRNA is present in SMN cytoplasmic complexes in SHSY5Y cells.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
| Journal or Publication Title: | Journal of Molecular Biology | ||||
| Publisher: | Academic Press | ||||
| ISSN: | 0022-2836 | ||||
| Official Date: | 3 September 2010 | ||||
| Dates: |
|
||||
| Volume: | 401 | ||||
| Number: | 5 | ||||
| Page Range: | pp. 681-689 | ||||
| DOI: | 10.1016/j.jmb.2010.06.058 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
