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The human microbiome and host–pathogen interactions
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Pallen, Mark J. (2011) The human microbiome and host–pathogen interactions. In: Nelson, Karen, (ed.) Metagenomics of the Human Body. New York: Springer-Verlag New York, pp. 43-61. ISBN 9781441970886
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Official URL: http://dx.doi.org/10.1007/978-1-4419-7089-3_3
Abstract
In the late nineteenth century, Robert Koch and his associates devised what are now known as Koch’s postulates (Koch, 1884; Koch, 1892) to establish a causal relationship between a specific disease and a single pathogenic microorganism, capable of causing disease after growth in pure culture. A century or so later, Falkow formulated “molecular Koch’s postulates” (Falkow, 1988) to provide a set of experimental
criteria to identify virulence factors in bacterial pathogens: (a) a gene is hypothesised to contribute to a virulence-related phenotype to the bacterium under study, (b) inactivation of the gene abolishes the phenotype, (c) reintroduction of the gene restores the wild-type phenotype to the mutant
Item Type: | Book Item | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Publisher: | Springer-Verlag New York | ||||
Place of Publication: | New York | ||||
ISBN: | 9781441970886 | ||||
Book Title: | Metagenomics of the Human Body | ||||
Editor: | Nelson, Karen | ||||
Official Date: | 2011 | ||||
Dates: |
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Number of Pages: | 351 | ||||
Page Range: | pp. 43-61 | ||||
DOI: | 10.1007/978-1-4419-7089-3_3 | ||||
Status: | Not Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
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