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Microbial TIR domains : not necessarily agents of subversion?

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Spear, Abigail M., Loman, Nicholas J., Atkins, Helen S. and Pallen, Mark J. (2009) Microbial TIR domains : not necessarily agents of subversion? Trends in Microbiology, 17 (9). pp. 393-398. doi:10.1016/j.tim.2009.06.005

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Official URL: http://dx.doi.org/10.1016/j.tim.2009.06.005

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Abstract

The Toll/interleukin-1 receptor (TIR) domain plays a crucial role in the mammalian innate immune response. Recently, proteins containing TIR domains have been described in bacteria and it has been suggested that these bacterial proteins are involved in subversion of the vertebrate immune system. Here we describe the distribution of TIR-domain proteins among bacteria, fungi, archaea and viruses and evaluate the subversion hypothesis in the light of our findings. We suggest that most TIR domains in bacteria have nothing to do with subverting eukaryotic cells; instead, TIR domains function simply as general purpose protein-protein interaction domains put to diverse uses.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Trends in Microbiology
Publisher: Elsevier Ltd
ISSN: 0966-842X
Official Date: 2009
Dates:
DateEvent
2009Published
Volume: 17
Number: 9
Page Range: pp. 393-398
DOI: 10.1016/j.tim.2009.06.005
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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