Harrison, Paul Michael, Badel, Laurent, Wall, Mark J. and Richardson, Magnus J. E. (2015) Experimentally verified parameter sets for modelling heterogeneous neocortical pyramidal-cell populations. PLoS Computational Biology, 11 (8). pp. 1-23. e1004165. doi:10.1371/journal.pcbi.1004165 ISSN 1553-7358.

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Abstract

Models of neocortical networks are increasingly including the diversity of excitatory and inhibitory neuronal classes. Significant variability in cellular properties are also seen within a nominal neuronal class and this heterogeneity can be expected to influence the population response and information processing in networks. Recent studies have examined the population and network effects of variability in a particular neuronal parameter with some plausibly chosen distribution. However, the empirical variability and covariance seen across multiple parameters are rarely included, partly due to the lack of data on parameter correlations in forms convenient for model construction. To addess this we quantify the heterogeneity within and between the neocortical pyramidal-cell classes in layers 2/3, 4, and the slender-tufted and thick-tufted pyramidal cells of layer 5 using a combination of intracellular recordings, single-neuron modelling and statistical analyses. From the response to both square-pulse and naturalistic fluctuating stimuli, we examined the class-dependent variance and covariance of electrophysiological parameters and identify the role of the h current in generating parameter correlations. A byproduct of the dynamic I-V method we employed is the straightforward extraction of reduced neuron models from experiment. Empirically these models took the refractory exponential integrate-and-fire form and provide an accurate fit to the perisomatic voltage responses of the diverse pyramidal-cell populations when the class-dependent statistics of the model parameters were respected. By quantifying the parameter statistics we obtained an algorithm which generates populations of model neurons, for each of the four pyramidal-cell classes, that adhere to experimentally observed marginal distributions and parameter correlations. As well as providing this tool, which we hope will be of use for exploring the effects of heterogeneity in neocortical networks, we also provide the code for the dynamic I-V method and make the full electrophysiological data set available.

Item Type:	Journal Article
Subjects:	Q Science > QP Physiology
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH):	Neocortex, Pyramidal tract
Journal or Publication Title:	PLoS Computational Biology
Publisher:	Public Library of Science
ISSN:	1553-7358
Official Date:	20 August 2015
Dates:	Date Event 20 August 2015 Published 30 January 2015 Accepted 13 October 2014 Submitted
Volume:	11
Number:	8
Number of Pages:	23
Page Range:	pp. 1-23
Article Number:	e1004165
DOI:	10.1371/journal.pcbi.1004165
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	10 December 2015
Date of first compliant Open Access:	10 December 2015
Funder:	Engineering and Physical Sciences Research Council (EPSRC)
Grant number:	EP/F500378/1 (EPSRC)

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