Bingle, Lewis E. H., Bailey, Christopher M. and Pallen, Mark J. (2008) Type VI secretion : a beginner's guide. Current Opinion in Microbiology, 11 (1). pp. 3-8. doi:10.1016/j.mib.2008.01.006 ISSN 1369-5274.

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Abstract

Type VI secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negative bacteria. Components that have been partially characterised include an IcmF homologue, the ATPase ClpV, a regulatory FHA domain protein and the secreted VgrG and Hcp proteins. Type VI secretion is clearly a key virulence factor for some important pathogenic bacteria and has been implicated in the translocation of a potential effector protein into eukaryotic cells by at least one organism (Vibrio cholerae). However, type VI secretion systems (T6SSs) are widespread in nature and not confined to known pathogens. In accordance with the general rule that the expression of protein secretion systems is tightly regulated, expression of type VI secretion is controlled at both transcriptional and post-transcriptional levels.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	Current Opinion in Microbiology
Publisher:	Elsevier Ltd
ISSN:	1369-5274
Official Date:	2008
Dates:	Date Event 2008 Published
Volume:	11
Number:	1
Page Range:	pp. 3-8
DOI:	10.1016/j.mib.2008.01.006
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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