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The WXG100 protein secretion system of streptococcus agalactiae
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Attwood, N., Whitehead, R., Shukla, A., Parikh, R., Pallen, Mark J. and Anthony, M. (2007) The WXG100 protein secretion system of streptococcus agalactiae. In: Neonatal Society 2007 Summer Meeting, Portsmouth, 28-29 Jun 2007. Published in: Neonatal Society Abstracts, Summer 2007
Research output not available from this repository, contact author.Abstract
Purpose of the Study: Mycobacterium tuberculosis secretes WXG100 proteins (100 amino acids long containing a WXG motif) through a WXG100 secretion system (Wss) into the external environment (1). WXG100 proteins signal to macrophages, for instance reducing cytokine release and causing granuloma formation (2). The Wss is essential for the virulence of TB (3,4). A Wss has also recently been described in Staphylococcus aureus, where it is also vital for full virulence of the organism (5). We sought to determine whether Streptococcus agalactiae (Group B streptococcus; GBS) also encodes Wss and WXG100 proteins.
Experimental design: We BLAST searched each of the eight genes (SA0271-0278) encoding the S. aureus Wss against the eight available GBS genomes. GBS genes were aligned to determine conservation of a putative Wss across the GBS sequenced strains, and the wider region was compared to define the genomic context.
Results: A putative Wss does exist in GBS (see Figure), and is conserved across the sequenced strains. esxAB are WXG100 homologs, essA-C and esaA-C encode homologs of proteins that are essential or accessory, respectively, to the function of the Wss in S. aureus. GBS genomes contain three WXG100 homologs, only one of which is associated with the Wss. The Wss is located within the genome on a mobile segment of DNA, termed ‘Putative Pathogenicity Island-IX’, implying that the Wss has been acquired by horizontal transfer. Similarly, the two WXG100 genes that are not associated with the Wss are also located in Putative Pathogenicity Islands -I and –XIII.
| Item Type: | Conference Item (Paper) | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Neonatal Society Abstracts | ||||
| Publisher: | The Neonatal Society | ||||
| Official Date: | 2007 | ||||
| Dates: |
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| Volume: | Summer 2007 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Conference Paper Type: | Paper | ||||
| Title of Event: | Neonatal Society 2007 Summer Meeting | ||||
| Type of Event: | Conference | ||||
| Location of Event: | Portsmouth | ||||
| Date(s) of Event: | 28-29 Jun 2007 | ||||
| Related URLs: |
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