X-epilectin: a novel epidermal fucolectin regulated by BMP signalling
UNSPECIFIED. (2004) X-epilectin: a novel epidermal fucolectin regulated by BMP signalling. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 48 (10). pp. 1119-1129. ISSN 0214-6282Full text not available from this repository.
Official URL: http://dx.doi.org/10.1387/ijdb.041892km
This paper reports the cloning and characterisation of a new posterior epidermal marker, X-epilectin, in Xenopus laevis. This gene encodes for a fucolectin, which belongs to the lectin superfamily of carbohydrate binding proteins and specifically binds fucose residues. RT-PCR and in situ hybridisation show that the expression of this gene is switched on during gastrulation and up-regulated during neurula stages and found expressed ubiquitously throughout the epidermis. From tailbud stages, the expression is limited to the dorsal posterior region of the embryo, suggesting that X-epilectin expression is regulated along anteroposterior and dorsoventral gradients during development. In the adult, X-epilectin is mainly expressed in intestinal components, kidney, spinal cord and skin. The effects of growth factors on the regulation of X-epilectin were studied. Change of the fate of animal caps into cement gland or dorsal mesoderm induces a down-regulation of X-epilectin expression in explants treated respectively with ammonium chloride and activin A. We also show that X-epilectin expression is down-regulated by Noggin and tBR and that this effect is inhibited by BMP4 over-expression, suggesting X-epilectin expression is mediated by the BMP signalling pathway.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Journal or Publication Title:||INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY|
|Publisher:||U B C PRESS|
|Official Date:||December 2004|
|Number of Pages:||11|
|Page Range:||pp. 1119-1129|
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