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X-epilectin: a novel epidermal fucolectin regulated by BMP signalling
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UNSPECIFIED (2004) X-epilectin: a novel epidermal fucolectin regulated by BMP signalling. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 48 (10). pp. 1119-1129. doi:10.1387/ijdb.041892km ISSN 0214-6282.
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Official URL: http://dx.doi.org/10.1387/ijdb.041892km
Abstract
This paper reports the cloning and characterisation of a new posterior epidermal marker, X-epilectin, in Xenopus laevis. This gene encodes for a fucolectin, which belongs to the lectin superfamily of carbohydrate binding proteins and specifically binds fucose residues. RT-PCR and in situ hybridisation show that the expression of this gene is switched on during gastrulation and up-regulated during neurula stages and found expressed ubiquitously throughout the epidermis. From tailbud stages, the expression is limited to the dorsal posterior region of the embryo, suggesting that X-epilectin expression is regulated along anteroposterior and dorsoventral gradients during development. In the adult, X-epilectin is mainly expressed in intestinal components, kidney, spinal cord and skin. The effects of growth factors on the regulation of X-epilectin were studied. Change of the fate of animal caps into cement gland or dorsal mesoderm induces a down-regulation of X-epilectin expression in explants treated respectively with ammonium chloride and activin A. We also show that X-epilectin expression is down-regulated by Noggin and tBR and that this effect is inhibited by BMP4 over-expression, suggesting X-epilectin expression is mediated by the BMP signalling pathway.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
Journal or Publication Title: | INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | ||||
Publisher: | U B C PRESS | ||||
ISSN: | 0214-6282 | ||||
Official Date: | December 2004 | ||||
Dates: |
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Volume: | 48 | ||||
Number: | 10 | ||||
Number of Pages: | 11 | ||||
Page Range: | pp. 1119-1129 | ||||
DOI: | 10.1387/ijdb.041892km | ||||
Publication Status: | Published |
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