UNSPECIFIED. (2004) X-epilectin: a novel epidermal fucolectin regulated by BMP signalling. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 48 (10). pp. 1119-1129. ISSN 0214-6282

Full text not available from this repository.

Abstract

This paper reports the cloning and characterisation of a new posterior epidermal marker, X-epilectin, in Xenopus laevis. This gene encodes for a fucolectin, which belongs to the lectin superfamily of carbohydrate binding proteins and specifically binds fucose residues. RT-PCR and in situ hybridisation show that the expression of this gene is switched on during gastrulation and up-regulated during neurula stages and found expressed ubiquitously throughout the epidermis. From tailbud stages, the expression is limited to the dorsal posterior region of the embryo, suggesting that X-epilectin expression is regulated along anteroposterior and dorsoventral gradients during development. In the adult, X-epilectin is mainly expressed in intestinal components, kidney, spinal cord and skin. The effects of growth factors on the regulation of X-epilectin were studied. Change of the fate of animal caps into cement gland or dorsal mesoderm induces a down-regulation of X-epilectin expression in explants treated respectively with ammonium chloride and activin A. We also show that X-epilectin expression is down-regulated by Noggin and tBR and that this effect is inhibited by BMP4 over-expression, suggesting X-epilectin expression is mediated by the BMP signalling pathway.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Journal or Publication Title:	INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
Publisher:	U B C PRESS
ISSN:	0214-6282
Date:	December 2004
Volume:	48
Number:	10
Number of Pages:	11
Page Range:	pp. 1119-1129
Identification Number:	10.1387/ijdb.041892km
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/7443

Data sourced from Thomson Reuters' Web of Knowledge

Request changes to a record

Actions (login required)

View Item