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Neural correlates of executive attention in adults born very preterm
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Daamen, Marcel, Bäuml, Josef G., Scheef, Lukas, Meng, Chun, Jurcoane, Alina, Jaekel, Julia, Sorg, Christian, Busch, Barbara, Baumann, Nicole, Bartmann, Peter, Wolke, Dieter, Wohlschläger, Afra and Boecker, Henning (2015) Neural correlates of executive attention in adults born very preterm. NeuroImage: Clinical, 9 . pp. 581-591. doi:10.1016/j.nicl.2015.09.002 ISSN 2213-1582.
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Official URL: http://dx.doi.org/10.1016/j.nicl.2015.09.002
Abstract
Very preterm birth is associated with an increased prevalence of attention problems and may especially impair executive attention, i.e., top-down control of attentional selection in situations where distracting information interferes with the processing of task-relevant stimuli. While there are initial findings linking structural brain alterations in preterm-born individuals with attention problems, the functional basis of these problems are not well understood. The present study used an fMRI adaptation of the Attentional Network Test to examine the neural correlates of executive attention in a large sample of N = 86 adults born very preterm and/or with very low birth weight (VP/VLBW), and N = 100 term-born controls. Executive attention was measured by comparing task behavior and brain activations associated with the processing of incongruent vs. congruent arrow flanker stimuli. Consistent with subtle impairments of executive attention, the VP/VLBW group showed lower accuracy and a tendency for increased response times during the processing of incongruent stimuli. Both groups showed similar activation patters, especially within expected fronto-cingulo-parietal areas, but no significant between-group differences. Our results argue for a maintained attention-relevant network organization in high-functioning preterm born adults in spite of subtle deficits in executive attention. Gestational age and neonatal treatment variables showed associations with task behavior, and brain activation in the dorsal ACC and lateral occipital areas, suggesting that the degree of prematurity (and related neonatal complications) has subtle modulatory influences on executive attention processing.
Item Type: | Journal Article | ||||||||||
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Subjects: | B Philosophy. Psychology. Religion > BF Psychology | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Executive functions (Neuropsychology), Attention | ||||||||||
Journal or Publication Title: | NeuroImage: Clinical | ||||||||||
Publisher: | Elsevier BV | ||||||||||
ISSN: | 2213-1582 | ||||||||||
Official Date: | 2015 | ||||||||||
Dates: |
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Volume: | 9 | ||||||||||
Number of Pages: | 11 | ||||||||||
Page Range: | pp. 581-591 | ||||||||||
DOI: | 10.1016/j.nicl.2015.09.002 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Date of first compliant deposit: | 4 December 2015 | ||||||||||
Date of first compliant Open Access: | 7 December 2015 | ||||||||||
Funder: | Germany. Bundesministerium für Bildung und Wissenschaft [Ministry of Education and Science], Universität München. Kommission für Klinische Forschung, Technische | ||||||||||
Grant number: | BMBF01ER0801, BMBF01ER0803, KKF 8765162 (KKF) |
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