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White matter alterations of the corticospinal tract in adults born very preterm and/or with very low birth weight
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Jurcoane, Alina, Daamen, Marcel, Scheef, Lukas, G. Bäuml, Josef, Meng, Chun, Wohlschläger, Afra, Sorg, Christian, Busch, Barbara, Baumann, Nicole, Wolke, Dieter, Bartmann, Peter, Hattingen, Elke and Boecker, Henning (2016) White matter alterations of the corticospinal tract in adults born very preterm and/or with very low birth weight. Human Brain Mapping, 37 (1). pp. 289-299. doi:10.1002/hbm.23031 ISSN 1065-9471.
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WRAP_0671038-ps-251115-jurcoane_et_al_2015_hbm-15-0404.r1-white_matter_corticospinal_tract_manuscript.pdf - Accepted Version - Requires a PDF viewer. Download (1134Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/hbm.23031
Abstract
White matter (WM) injury, either visible on conventional magnetic resonance images (MRI) or measurable by diffusion tensor imaging (DTI), is frequent in preterm born individuals and often affects the corticospinal tract (CST). The relation between visible and invisible white mater alterations in the reconstructed CST of preterm subjects has so far been studied in infants, children and up to adolescence. Therefore, we probabilistically tracked the CST in 53 term-born and 56 very preterm and/or low birth weight (VP/VLBW, < 32 weeks of gestation and/or birth weight < 1,500 g) adults (mean age 26 years) and compared their DTI parameters (axial, radial, mean diffusivity—AD, RD, MD, fractional anisotropy—FA) in the whole CST and slice-wise along the CST. Additionally, we used the automatic, tract-based-spatial-statistics (TBSS) as an alternative to tractography. We compared control and VP/VLBW and subgroups with and without CST WM lesions visible on conventional MRI. Compared to controls, VP/VLBW subjects had significantly higher diffusivity (AD, RD, MD) in the whole CST, slice-wise along the CST, and in multiple regions along the TBSS skeleton. VP/VLBW subjects also had significantly lower (TBSS) and higher (tractography) FA in regions along the CST, but no different mean FA in the tracked CST as a whole. Diffusion changes were weaker, but remained significant for both, tractography and TBSS, when excluding subjects with visible CST lesions. Chronic CST injury persists in VP/VLBW adults even in the absence of visible WM lesions, indicating long-term structural WM changes induced by premature birth.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | R Medicine > RJ Pediatrics | ||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Premature infants, Brain -- Wounds and injuries | ||||||||||
| Journal or Publication Title: | Human Brain Mapping | ||||||||||
| Publisher: | John Wiley and Sons | ||||||||||
| ISSN: | 1065-9471 | ||||||||||
| Official Date: | January 2016 | ||||||||||
| Dates: |
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| Volume: | 37 | ||||||||||
| Number: | 1 | ||||||||||
| Page Range: | pp. 289-299 | ||||||||||
| DOI: | 10.1002/hbm.23031 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||
| Date of first compliant deposit: | 9 December 2015 | ||||||||||
| Date of first compliant Open Access: | 21 October 2016 | ||||||||||
| Funder: | Germany. Bundesministerium für Bildung und Forschung (BMBF), Technische Universität München. Kommission für Klinische Forschung |
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