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Validation of digital pathology imaging for primary histopathological diagnosis
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Snead, David R. J., Tsang, Yee-Wah, Meskiri, Aisha, Kimani, Peter K., Crossman, Richard, Rajpoot, Nasir M., Blessing, Elaine, Chen, Klaus, Gopalakrishnan, Kishore, Matthews, Paul, Momtahan, Navid, Read-Jones, Sarah, Sah, Shatrughan, Simmons, Emma, Sinha, Bidisa, Suortamo, Sari, Yeo, Yen, El Daly, Hesham and Cree, Ian A. (2016) Validation of digital pathology imaging for primary histopathological diagnosis. Histopathology, 68 (7). pp. 1063-1072. doi:10.1111/his.12879 ISSN 0309-0167.
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Official URL: http://dx.doi.org/10.1111/his.12879
Abstract
Aims:
Digital pathology (DP) offers advantages over glass slide microscopy (GS), but data demonstrating a statistically valid equivalent (i.e. non-inferior) performance of DP against GS are required to permit its use in diagnosis. The aim of this study is to provide evidence of non-inferiority.
Methods and results:
Seventeen pathologists re-reported 3017 cases by DP. Of these, 1009 were re-reported by the same pathologist, and 2008 by a different pathologist. Re-examination of 10 138 scanned slides (2.22 terabytes) produced 72 variances between GS and DP reports, including 21 clinically significant variances. Ground truth lay with GS in 12 cases and with DP in nine cases. These results are within the 95% confidence interval for existing intraobserver and interobserver variability, proving that DP is non-inferior to GS. In three cases, the digital platform was deemed to be responsible for the variance, including a gastric biopsy, where Helicobacter pylori only became visible on slides scanned at the ×60 setting, and a bronchial biopsy and penile biopsy, where dysplasia was reported on DP but was not present on GS.
Conclusions:
This is one of the largest studies proving that DP is equivalent to GS for the diagnosis of histopathology specimens. Error rates are similar in both platforms, although some problems e.g. detection of bacteria, are predictable.
Item Type: | Journal Article | ||||||||||
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Subjects: | R Medicine > RA Public aspects of medicine | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Diagnostic imaging, Image processing -- Digital techniques, Computer programs -- Validation | ||||||||||
Journal or Publication Title: | Histopathology | ||||||||||
Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||||
ISSN: | 0309-0167 | ||||||||||
Official Date: | June 2016 | ||||||||||
Dates: |
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Volume: | 68 | ||||||||||
Number: | 7 | ||||||||||
Number of Pages: | 10 | ||||||||||
Page Range: | pp. 1063-1072 | ||||||||||
DOI: | 10.1111/his.12879 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 11 December 2015 | ||||||||||
Date of first compliant Open Access: | 14 December 2015 | ||||||||||
Funder: | Omnyx (Firm) |
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