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Genome sequence of the non-pathogenic strain 15 of pneumonia virus of mice and comparison with the genome of the pathogenic strain J3666
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UNSPECIFIED. (2005) Genome sequence of the non-pathogenic strain 15 of pneumonia virus of mice and comparison with the genome of the pathogenic strain J3666. JOURNAL OF GENERAL VIROLOGY, 86 (Part 1). pp. 159-169. ISSN 0022-1317
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Official URL: http://dx.doi.org/10.1099/vir.0.80315-0
Abstract
Pneumonia virus of mice (PVM) is a member of the subfamily Pneumovirinae and is the closest known relative of respiratory syncytial virus. Both viruses cause pneumonia in their respective hosts. Here, the genome sequences of two strains of PVM, non-pathogenic strain 15 and pathogenic strain J3666, are reported. Comparison of the genome sequences revealed 59 nucleotide differences between the two strains, 37 of which were coding. The nucleotide differences were spread throughout the genome, affecting cis-acting regulatory regions and seven of the ten genes. Development of a reverse-genetics system for PVM should allow further elucidation of the functional importance of the genetic differences between the two strains identified here.
| Item Type: | Journal Article |
|---|---|
| Subjects: | T Technology > TP Chemical technology Q Science > QR Microbiology > QR355 Virology |
| Journal or Publication Title: | JOURNAL OF GENERAL VIROLOGY |
| Publisher: | SOC GENERAL MICROBIOLOGY |
| ISSN: | 0022-1317 |
| Date: | January 2005 |
| Volume: | 86 |
| Number: | Part 1 |
| Number of Pages: | 11 |
| Page Range: | pp. 159-169 |
| Identification Number: | 10.1099/vir.0.80315-0 |
| Publication Status: | Published |
| URI: | http://wrap.warwick.ac.uk/id/eprint/7485 |
Data sourced from Thomson Reuters' Web of Knowledge
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