Genetic analysis of diverse disease-causing pneumococci indicates high levels of diversity within serotypes and capsule switching
UNSPECIFIED. (2004) Genetic analysis of diverse disease-causing pneumococci indicates high levels of diversity within serotypes and capsule switching. JOURNAL OF CLINICAL MICROBIOLOGY, 42 (12). pp. 5681-5688. ISSN 0095-1137Full text not available from this repository.
Official URL: http://dx.doi.org/10.1128/JCM.42.12.5681-5688.2004
We have used multilocus sequence typing (MLST) and serotyping to build a phylogenetic framework for pneumococcal disease isolates in Scotland that provides a snapshot of the relationships between capsular type and genotype. The results show that while the MLST type correlates with the serotype, isolates within a serotype can belong to a number of individual clonal complexes or sequence types (STs). We also show that isolates of the same ST can express different capsular polysaccharides, i.e., display capsular switching, and that this phenomenon is observed both for capsular types commonly isolated from patients with invasive disease and for serogroups less commonly isolated from patients with invasive disease but which may commonly be carried a symptomatically in the human nasopharynx.
|Item Type:||Journal Article|
|Subjects:||Q Science > QR Microbiology|
|Journal or Publication Title:||JOURNAL OF CLINICAL MICROBIOLOGY|
|Publisher:||AMER SOC MICROBIOLOGY|
|Official Date:||December 2004|
|Number of Pages:||8|
|Page Range:||pp. 5681-5688|
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