UNSPECIFIED. (2005) PiuA and PiaA, iron uptake lipoproteins of Streptococcus pneumoniae, elicit serotype independent antibody responses following human pneumococcal septicaemia. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 43 (1). pp. 73-80. ISSN 0928-8244

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Abstract

Streptococcus pneumoniae causes considerable morbidity and mortality worldwide. The need for a cheap and effective pneumococcal vaccine has necessitated the evaluation of common virulence-associated proteins as potential vaccine antigens. PiuA and PiaA are the lipoprotein components of two pneumococcal iron ABC transporters. Here, we show that patients with culture confirmed pneumococcal septicaemia have elevated levels of antibody to PiuA and PiaA in convalescent-phase, compared with acute-phase serum. Additionally, sera from septicaemic patients infected with 13 pneumococcal strains covering eight different serotypes, cross-reacted with recombinant PiuA-His(6) and PiaA-His(6) from a single pneumococcal strain, indicating that this immune response is serotype independent. Anti-PiuA and anti-PiaA antibodies were also found in healthy seven-month-old infants, indicating that they are immunogenic at a very early age. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR180 Immunology Q Science > QR Microbiology > QR355 Virology Q Science > QR Microbiology
Journal or Publication Title:	FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Publisher:	ELSEVIER SCIENCE BV
ISSN:	0928-8244
Date:	1 January 2005
Volume:	43
Number:	1
Number of Pages:	8
Page Range:	pp. 73-80
Identification Number:	10.1016/j.femism.2004.07.010
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/7527

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