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Temporal changes in pneumococcal colonization in HIV-infected and HIV-uninfected mother-child pairs following transitioning from 7-valent to 13-valent pneumococcal conjugate vaccine, Soweto, South Africa
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Nzenze, Susan A., von Gottberg, Anne, Shiri, Tinevimbo, van Niekerk, Nadia, de Gouveia, Linda, Violari, Avy, Nunes, Marta C. and Madhi, Shabir A. (2015) Temporal changes in pneumococcal colonization in HIV-infected and HIV-uninfected mother-child pairs following transitioning from 7-valent to 13-valent pneumococcal conjugate vaccine, Soweto, South Africa. The Journal of Infectious Diseases, 212 (7). pp. 1082-1092. doi:10.1093/infdis/jiv167 ISSN 0022-1899.
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Official URL: http://dx.doi.org/10.1093/infdis/jiv167
Abstract
Background. We investigated the impact of infant pneumococcal conjugate vaccine (PCV) immunization on pneumococcal colonization among human immunodeficiency virus (HIV)–infected and HIV-uninfected mother-child pairs.
Methods. Pneumococcal colonization was assessed in May 2010–February 2011 (period 1; 7-valent PCV era) and May 2012–April 2013 (period 2; 13-valent PCV era). Standard microbiological methods were used for pneumococcus isolation and serotyping.
Results. In children 0–12 years, PCV13-serotype colonization decreased from period 1 to period 2 among HIV-uninfected (adjusted odds ratio [OR], 0.32; 95% confidence interval [CI], .25–.40) and HIV-infected children (adjusted OR, 0.37; 95% CI, .28–.49), while there was an increase in nonvaccine serotype colonization. Decreases in PCV13-serotype colonization were observed in HIV-uninfected women (adjusted OR, 0.44; 95% CI, .23–.81), with a similar trend in HIV-infected women. HIV-infected compared to -uninfected women had higher prevalence of overall (20.5% vs 9.7% in period 1; 13.8% vs 9.7% in period 2) and PCV13-serotype colonization (8.7% vs 5.4% in period 1; 4.8% vs 2.0% in period 2), P < .04 for all observations.
Conclusions. Targeted PCV vaccination of African infants in a setting with high HIV prevalence was associated with PCV13-serotype colonization reduction, including among unvaccinated HIV-infected women.
Item Type: | Journal Article | ||||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | The Journal of Infectious Diseases | ||||||||||
Publisher: | Oxford University Press | ||||||||||
ISSN: | 0022-1899 | ||||||||||
Official Date: | 2015 | ||||||||||
Dates: |
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Volume: | 212 | ||||||||||
Number: | 7 | ||||||||||
Page Range: | pp. 1082-1092 | ||||||||||
DOI: | 10.1093/infdis/jiv167 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access |
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