Melegaro, Alessia, Gay, N. J. and Medley, Graham (2004) Estimating the transmission parameters of pneumococcal carriage in households. Epidemiology and Infection, Vol.132 (No.3). pp. 433-441. doi:10.1017/S0950268804001980 ISSN 0950-2688.

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Abstract

This paper analyses Streptococcus pneumoniae transmission dynamics in households using longitudinal data on pneumococcal (Pnc) carriage in the United Kingdom. Ten consecutive swabs were taken at 4-week intervals from all members of 121 households. The family status is derived from the observed Pnc carriage status of each family member. Transition matrices are built for each family size and composition containing the observed frequency of transitions between family statuses over a 28-day interval. A density-dependent transmission model is fitted to derive maximum-likelihood estimates of the duration of carriage and acquisition rates from the community and from infected individuals within the household. Parameter values are estimated for children (<5 years) and adults (5+years). The duration of carriage is longer in children <5 years of age than in older family members (51 vs. 19 days). Children are 3–4 times more likely than adults to acquire Pnc infection from the community. Transmission rates within the household suggest that adults are more infectious but less susceptible than children. Transmission within the household is most important in large families. The proportion of household-acquired infection ranges from 29 to 46% in households of three persons to 38–50% in larger households. Evidence of density-dependent within-household transmission is found, although the strength of this relationship is not clear from the model estimates.

Item Type:	Journal Article
Subjects:	R Medicine > RB Pathology R Medicine > RA Public aspects of medicine
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Library of Congress Subject Headings (LCSH):	Streptococcus pneumoniae, Communicable diseases -- Transmission, Respiratory infections, Epidemiology -- Research
Journal or Publication Title:	Epidemiology and Infection
Publisher:	Cambridge University Press
ISSN:	0950-2688
Official Date:	June 2004
Dates:	Date Event June 2004 Published
Volume:	Vol.132
Number:	No.3
Page Range:	pp. 433-441
DOI:	10.1017/S0950268804001980
Status:	Peer Reviewed
Access rights to Published version:	Open Access (Creative Commons)
Funder:	European Union (EU)
Grant number:	QLG4-CT-2000- 00640 (EU)

Data sourced from Thomson Reuters' Web of Knowledge

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