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Enhancement of selectivity of an organometallic anticancer agent by redox modulation

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Romero-Canelón, Isolda, Mos, Magdalena and Sadler, P. J. (2015) Enhancement of selectivity of an organometallic anticancer agent by redox modulation. Journal of Medicinal Chemistry, 58 (19). pp. 7874-7880. doi:10.1021/acs.jmedchem.5b00655 ISSN 0022-2623.

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Official URL: http://dx.doi.org/10.1021/acs.jmedchem.5b00655

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Abstract

Combination with redox modulators can potentiate the anticancer activity and maximize the selectivity of organometallic complexes with redox-based mechanisms of action. We show that nontoxic doses of l-buthionine sulfoximine increase the selectivity of organo-Os complex FY26 for human ovarian cancer cells versus normal lung fibroblasts to 63-fold. This increase is not due to changes in the mechanism of action of FY26 but to the decreased response of cancer cells to oxidative stress.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Antineoplastic agents, Antioncogenes
Journal or Publication Title: Journal of Medicinal Chemistry
Publisher: American Chemical Society
ISSN: 0022-2623
Official Date: 23 September 2015
Dates:
DateEvent
23 September 2015Published
29 April 2015Submitted
Volume: 58
Number: 19
Page Range: pp. 7874-7880
DOI: 10.1021/acs.jmedchem.5b00655
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 13 January 2016
Date of first compliant Open Access: 18 February 2016
Funder: European Research Council (ERC), Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Engineering and Physical Sciences Research Council (EPSRC), Economic and Social Research Council (Great Britain) (ESRC)
Grant number: 247450 ERC, 324594 ERC,

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