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Enhancement of selectivity of an organometallic anticancer agent by redox modulation
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Romero-Canelón, Isolda, Mos, Magdalena and Sadler, P. J. (2015) Enhancement of selectivity of an organometallic anticancer agent by redox modulation. Journal of Medicinal Chemistry, 58 (19). pp. 7874-7880. doi:10.1021/acs.jmedchem.5b00655 ISSN 0022-2623.
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Official URL: http://dx.doi.org/10.1021/acs.jmedchem.5b00655
Abstract
Combination with redox modulators can potentiate the anticancer activity and maximize the selectivity of organometallic complexes with redox-based mechanisms of action. We show that nontoxic doses of l-buthionine sulfoximine increase the selectivity of organo-Os complex FY26 for human ovarian cancer cells versus normal lung fibroblasts to 63-fold. This increase is not due to changes in the mechanism of action of FY26 but to the decreased response of cancer cells to oxidative stress.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||
| Library of Congress Subject Headings (LCSH): | Antineoplastic agents, Antioncogenes | ||||||
| Journal or Publication Title: | Journal of Medicinal Chemistry | ||||||
| Publisher: | American Chemical Society | ||||||
| ISSN: | 0022-2623 | ||||||
| Official Date: | 23 September 2015 | ||||||
| Dates: |
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| Volume: | 58 | ||||||
| Number: | 19 | ||||||
| Page Range: | pp. 7874-7880 | ||||||
| DOI: | 10.1021/acs.jmedchem.5b00655 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 13 January 2016 | ||||||
| Date of first compliant Open Access: | 18 February 2016 | ||||||
| Funder: | European Research Council (ERC), Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Engineering and Physical Sciences Research Council (EPSRC), Economic and Social Research Council (Great Britain) (ESRC) | ||||||
| Grant number: | 247450 ERC, 324594 ERC, |
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