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Structural determinants in a library of low molecular weight gelators
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Morris, Kyle L., Chen, Lin, Rodger, Alison, Adams, Dave J. and Serpell, Louise C. (2015) Structural determinants in a library of low molecular weight gelators. Soft Matter, 11 (6). pp. 1174-1181. doi:10.1039/c4sm02532f ISSN 1744-683X.
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WRAP_9471544-ch-050116-morris-et-al-revision_copy.pdf - Accepted Version - Requires a PDF viewer. Download (3348Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/C4SM02532F
Abstract
Low molecular weight hydrogels are formed by molecules that form a matrix that immobilises water to form a self-supporting gel. Such gels have uses as biomaterials such as molecular scaffolds and structures for tissue engineering. One class of low molecular weight gelator (LMWG), naphthalene-conjugated dipeptides, has been shown to form hydrogels via self-assembly following a controlled drop in pH. A library of naphthalene-dipeptides has been generated previously although the relationship between the precursor sequence and the resulting self-assembled structures remained unclear. Here, we have investigated the structural details of a set of dipeptide sequences containing alanine (A) and valine (V) conjugated to naphthalene groups substituted with a Br, CN or H at the 6-position. Electron microscopy, circular dichroism and X-ray fibre diffraction shows that these LMWG may be structurally classified by their composition: the molecular packing is determined by the class of conjugate, whilst the chirality of the self-assemblies can be attributed to the dipeptide sequence. This provides insights into the relationship between the precursor sequence and the macromolecular and molecular structures of the fibres that make up the resulting hydrogels.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Library of Congress Subject Headings (LCSH): | Supramolecular chemistry, Colloids, Nanostructured materials, Polymers, Gelation, Soft condensed matter | ||||||||
Journal or Publication Title: | Soft Matter | ||||||||
Publisher: | Royal Society of Chemistry | ||||||||
ISSN: | 1744-683X | ||||||||
Official Date: | 14 February 2015 | ||||||||
Dates: |
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Volume: | 11 | ||||||||
Number: | 6 | ||||||||
Page Range: | pp. 1174-1181 | ||||||||
DOI: | 10.1039/c4sm02532f | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 13 January 2016 | ||||||||
Date of first compliant Open Access: | 30 May 2016 | ||||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC) | ||||||||
Grant number: | EP/G012741/1 |
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