Leng, Daniel J., Black, Conor and Pattison, Graham (2016) One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process. Organic and Biomolecular Chemistry, 172 . doi:10.1039/c5ob02468d ISSN 1477-0520.

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Abstract

Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragmentation of 1-trifluoromethyl-1,3-diketones which should now allow the chemistry of difluoromethyl ketones to be fully developed.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH):	Ketones, Drugs -- Design, Organic compounds -- Synthesis
Journal or Publication Title:	Organic and Biomolecular Chemistry
Publisher:	RSC
ISSN:	1477-0520
Official Date:	2016
Dates:	Date Event 2016 Published 16 December 2015 Published 16 December 2015 Accepted 2 December 2015 Submitted
Volume:	172
DOI:	10.1039/c5ob02468d
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Date of first compliant deposit:	19 January 2016
Date of first compliant Open Access:	16 December 2017
Funder:	Royal Society (Great Britain)

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