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Predictive factors for response to abiraterone in metastatic castration refractory prostate cancer
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Afshar, Mehran, Al-Alloosh , F., Pirrie, S., Rowan, C., James, Nicholas D. and Porfiri, E. (2015) Predictive factors for response to abiraterone in metastatic castration refractory prostate cancer. Anticancer Research, 35 (2). pp. 1057-1063. ISSN 0250-7005.
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Official URL: http://ar.iiarjournals.org/content/35/2/1057.full....
Abstract
BACKGROUND:
Management of metastatic castration refractory prostate cancer (CRPC) is rapidly evolving. Rationalisation of treatment requires identification of those patients more likely to benefit from a particular therapy. We reviewed the outcome of patients treated with abiraterone at our Institution to describe factors predictive for response.
PATIENTS AND METHODS:
Patients with CRCP treated with abiraterone were identified. Baseline variables and potential prognostic factors were extracted from electronic records. Outcome measures included overall survival (OS), prostate-specific antigen (PSA) response and time to PSA progression (TTPP). The Kaplan-Meier method and Cox proportional hazards model were used to analyze survival data.
RESULTS:
A total of 61 patients met the inclusion criteria. In multivariate analysis, three independent predictors of OS were identified: Duration of response to androgen deprivation therapy (ADT) (hazard ratio(HR)=0.95, p=0.006), performance status (HR=7.4, p=0.013), and baseline haemoglobin (HR=0.47, pā¤0.001).
CONCLUSION:
This study has identified three factors predictive for response to abiraterone in CRPC. Duration of response to ADT has not been previously shown to be a predictive factor for patients with CRCP. We suggest that a prospective validation is required
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Cancer Research Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Anticancer Research | ||||||||
Publisher: | Int Ins of Anticancer Research | ||||||||
ISSN: | 0250-7005 | ||||||||
Official Date: | February 2015 | ||||||||
Dates: |
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Volume: | 35 | ||||||||
Number: | 2 | ||||||||
Page Range: | pp. 1057-1063 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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