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Re : defining progression in nonmuscle invasive bladder cancer : it is time for a new, standard definition
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Bryan, Richard T., Cheng, K. K. , James, Nicholas D., Zeegers, Maurice P. and Wallace, D. M. A. (2014) Re : defining progression in nonmuscle invasive bladder cancer : it is time for a new, standard definition. The Journal of Urology, 191 (6). pp. 1930-1931. doi:10.1016/j.juro.2014.01.011 ISSN 0022-5347.
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Official URL: http://dx.doi.org/10.1016/j.juro.2014.01.011
Abstract
We are in agreement with Lamm et al regarding the need for a new standard definition to describe progression of nonmuscle invasive bladder cancer (NMIBC). We, too, recognized that defining a state of progression before the development of muscle invasion would be a useful tool for clinical trials of patients with NMIBC. Consequently in 2005 we went through a similar process when writing the protocol for the West Midlands (United Kingdom) Bladder Cancer Prognosis Programme (BCPP, incorporating SELENIB [Selenium and Vitamin E Trial in Non-Muscle Invasive Bladder Cancer]), defining progression as “a recurrence with an increase in tumor grade from 1/2 to grade 3, or an increase in TNM stage, or the new occurrence of carcinoma in situ (CIS) in a bladder previously free from such lesions, or the new occurrence of multiple tumors following resection of a solitary tumor, or the need for a cystectomy because of refractory disease.”1 Clearly there are many similarities between our definition of progression for the purposes of BCPP/SELENIB and that proposed by Lamm et al, and we support their rationale and endeavor.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Cancer Research Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | The Journal of Urology | ||||||
Publisher: | Elsevier Inc. | ||||||
ISSN: | 0022-5347 | ||||||
Official Date: | June 2014 | ||||||
Dates: |
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Volume: | 191 | ||||||
Number: | 6 | ||||||
Page Range: | pp. 1930-1931 | ||||||
DOI: | 10.1016/j.juro.2014.01.011 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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