Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

cncRNAs : Bi-functional RNAs with protein coding and non-coding functions

Tools
- Tools
+ Tools

Kumari, Pooja and Sampath, Karuna (2015) cncRNAs : Bi-functional RNAs with protein coding and non-coding functions. Seminars in Cell & Developmental Biology, 47-48 . pp. 40-51. doi:10.1016/j.semcdb.2015.10.024

[img] PDF
WRAP_1-s2.0-S1084952115002219-main.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (1832Kb)
Official URL: http://dx.doi.org/10.1016/j.semcdb.2015.10.024

Request Changes to record.

Abstract

For many decades, the major function of mRNA was thought to be to provide protein-coding information embedded in the genome. The advent of high-throughput sequencing has led to the discovery of pervasive transcription of eukaryotic genomes and opened the world of RNA-mediated gene regulation. Many regulatory RNAs have been found to be incapable of protein coding and are hence termed as non-coding RNAs (ncRNAs). However, studies in recent years have shown that several previously annotated non-coding RNAs have the potential to encode proteins, and conversely, some coding RNAs have regulatory functions independent of the protein they encode. Such bi-functional RNAs, with both protein coding and non-coding functions, which we term as ‘cncRNAs’, have emerged as new players in cellular systems. Here, we describe the functions of some cncRNAs identified from bacteria to humans. Because the functions of many RNAs across genomes remains unclear, we propose that RNAs be classified as coding, non-coding or both only after careful analysis of their functions.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): RNA-protein interactions, Non-coding RNA, Genetic regulation
Journal or Publication Title: Seminars in Cell & Developmental Biology
Publisher: Elsevier Ltd
ISSN: 1084-9521
Official Date: December 2015
Dates:
DateEvent
December 2015Published
20 October 2015Published
Volume: 47-48
Number of Pages: 12
Page Range: pp. 40-51
DOI: 10.1016/j.semcdb.2015.10.024
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Friedrich-Miescher-Institut, Warwick Medical School

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us