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cncRNAs : Bi-functional RNAs with protein coding and non-coding functions
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Kumari, Pooja and Sampath, Karuna (2015) cncRNAs : Bi-functional RNAs with protein coding and non-coding functions. Seminars in Cell & Developmental Biology, 47-48 . pp. 40-51. doi:10.1016/j.semcdb.2015.10.024
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Official URL: http://dx.doi.org/10.1016/j.semcdb.2015.10.024
Abstract
For many decades, the major function of mRNA was thought to be to provide protein-coding information embedded in the genome. The advent of high-throughput sequencing has led to the discovery of pervasive transcription of eukaryotic genomes and opened the world of RNA-mediated gene regulation. Many regulatory RNAs have been found to be incapable of protein coding and are hence termed as non-coding RNAs (ncRNAs). However, studies in recent years have shown that several previously annotated non-coding RNAs have the potential to encode proteins, and conversely, some coding RNAs have regulatory functions independent of the protein they encode. Such bi-functional RNAs, with both protein coding and non-coding functions, which we term as ‘cncRNAs’, have emerged as new players in cellular systems. Here, we describe the functions of some cncRNAs identified from bacteria to humans. Because the functions of many RNAs across genomes remains unclear, we propose that RNAs be classified as coding, non-coding or both only after careful analysis of their functions.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology | ||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | RNA-protein interactions, Non-coding RNA, Genetic regulation | ||||||
| Journal or Publication Title: | Seminars in Cell & Developmental Biology | ||||||
| Publisher: | Elsevier Ltd | ||||||
| ISSN: | 1084-9521 | ||||||
| Official Date: | December 2015 | ||||||
| Dates: |
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| Date of first compliant deposit: | 27 January 2016 | ||||||
| Volume: | 47-48 | ||||||
| Number of Pages: | 12 | ||||||
| Page Range: | pp. 40-51 | ||||||
| DOI: | 10.1016/j.semcdb.2015.10.024 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Funder: | Friedrich-Miescher-Institut, Warwick Medical School |
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