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Advances in the molecular understanding of biological zinc transport
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Blindauer, Claudia A. (2015) Advances in the molecular understanding of biological zinc transport. Chemical Communications, 51 (22). pp. 4544-4563. doi:10.1039/c4cc10174j ISSN 1359-7345.
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Official URL: http://dx.doi.org/10.1039/C4CC10174J
Abstract
Between 5 and 10% of all proteins of a given organism are estimated to require zinc for function, and hence zinc is essential for almost any given metabolic process. It is therefore of great interest to understand major players and mechanisms that ensure the tight and correct control of zinc distribution and speciation in organisms and their individual cells. Significant progress has been made in recent years regarding 3-dimensional structures and modes of action of zinc sensor proteins, membrane-bound zinc transporters for cellular and sub-cellular uptake and efflux, as well as intracellular binding proteins. This feature article highlights advances in structures, zinc-binding sites and thermodynamics of proteins that are involved in zinc homeostasis and trafficking, including developments in understanding the metal selectivity of proteins.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QR Microbiology | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Library of Congress Subject Headings (LCSH): | Zinc enzymes, Zinc in the body | ||||||||
Journal or Publication Title: | Chemical Communications | ||||||||
Publisher: | Royal Society of Chemistry | ||||||||
ISSN: | 1359-7345 | ||||||||
Official Date: | 20 January 2015 | ||||||||
Dates: |
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Volume: | 51 | ||||||||
Number: | 22 | ||||||||
Number of Pages: | 20 | ||||||||
Page Range: | pp. 4544-4563 | ||||||||
DOI: | 10.1039/c4cc10174j | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 28 January 2016 | ||||||||
Date of first compliant Open Access: | 28 January 2016 | ||||||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Royal Society (Great Britain) | ||||||||
Grant number: | BB/J006467/1 (BBSRC) |
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