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The application of FAIMS gas analysis in medical diagnostics
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Covington, James A., van. der Schee, M. P., Edge, A. S. L., Boyle, B., Savage, R. S. and Arasaradnam, Ramesh P. (2015) The application of FAIMS gas analysis in medical diagnostics. The Analyst, 140 (20). pp. 6775-6781. doi:10.1039/c5an00868a ISSN 0003-2654.
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Official URL: http://dx.doi.org/10.1039/C5AN00868A
Abstract
There is an ever increasing need to develop new tools to aid in the diagnosis and monitoring of human diseases. Such tools will ultimately reduce the cost of healthcare by identifying disease states more quickly and cheaply than current practices. One method showing promise is the analysis of gas-phase biomarkers from human breath, urine, sweat and stool that reflect bodily metabolism. Analysis of these volatiles by GC MS requires specialised infra-structure and staff, making it unsuitable for a clinical setting. Point of care sensor based technologies such as eNoses often suffer from stability and sensitivity issues. Field-Asymmetric Ion Mobility Spectrometry (FAIMS) has potential to fulfil this clinical need. In this paper we review the medical need, the technology, sampling methods and medical evidence thus far. We conclude with reflecting on future developmental steps necessary to bring the device into medical practice.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Science > Statistics Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | The Analyst | ||||||||
| Publisher: | Royal Society of Chemistry | ||||||||
| ISSN: | 0003-2654 | ||||||||
| Official Date: | 17 July 2015 | ||||||||
| Dates: |
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| Volume: | 140 | ||||||||
| Number: | 20 | ||||||||
| Page Range: | pp. 6775-6781 | ||||||||
| DOI: | 10.1039/c5an00868a | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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