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Non-invasive exhaled volatile organic biomarker analysis to detect inflammatory bowel disease (IBD)

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Arasaradnam, Ramesh P., McFarlane, Michael J., Daulton, Emma, Skinner, Jim, O’Connell, Nicola, Wurie, Subiatu, Chambers, Samantha, Nwokolo, Chuka U., Bardhan, Karna Dev, Savage, Richard S. and Covington, James A. (2016) Non-invasive exhaled volatile organic biomarker analysis to detect inflammatory bowel disease (IBD). Digestive and Liver Disease, 48 (2). pp. 148-153. pii/S1590865815301067. doi:10.1016/j.dld.2015.10.013 ISSN 1590-8658.

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Official URL: http://dx.doi.org/10.1016/j.dld.2015.10.013

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Abstract

Early inflammatory bowel disease (IBD) diagnosis remains a clinical challenge. Volatile organic compounds (VOCs) have shown distinct patterns in Crohn's disease (CD) and ulcerative colitis (UC). VOC production, reflecting gut fermentome metabolites, is perturbed in IBD. VOC sampling is non-invasive, with various compounds identified from faecal, breath and urine samples. This study aimed to determine if FAIMS (field asymmetric ion mobility spectroscopy) analysis of exhaled VOCs could distinguish IBD from controls.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Research Centres > Centre for Complexity Science
Faculty of Science, Engineering and Medicine > Engineering > Engineering
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Digestive and Liver Disease
Publisher: W. B. Saunders Co. Ltd.
ISSN: 1590-8658
Official Date: 2 November 2016
Dates:
DateEvent
2 November 2016Published
22 November 2015Available
13 October 2015Accepted
11 August 2015Submitted
Volume: 48
Number: 2
Page Range: pp. 148-153
Article Number: pii/S1590865815301067
DOI: 10.1016/j.dld.2015.10.013
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
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