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Translational medicine and patient safety in Europe : TRANSFoRm—architecture for the learning health system in Europe
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Delaney, B., Curcin, Vasa, Andreasson, Anna, Arvanitis, Theodoros N., Bastiaens, Hilde, Corrigan, Derek, Ethier, Jean-Francois, Kostopoulou, Olga, Kuchinke, Wolfgang, McGilchrist, Mark, Royen, Paul van and Wagner, Peter (2015) Translational medicine and patient safety in Europe : TRANSFoRm—architecture for the learning health system in Europe. BioMed Research International, 2015 . doi:10.1155/2015/961526
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Official URL: http://dx.doi.org/10.1155/2015/961526
Abstract
The Learning Health System (LHS) describes linking routine healthcare systems directly with both research translation and knowledge translation as an extension of the evidence-based medicine paradigm, taking advantage of the ubiquitous use of electronic health record (EHR) systems. TRANSFoRm is an EU FP7 project that seeks to develop an infrastructure for the LHS in European primary care. Methods. The project is based on three clinical use cases, a genotype-phenotype study in diabetes, a randomised controlled trial with gastroesophageal reflux disease, and a diagnostic decision support system for chest pain, abdominal pain, and shortness of breath. Results. Four models were developed (clinical research, clinical data, provenance, and diagnosis) that form the basis of the projects approach to interoperability. These models are maintained as ontologies with binding of terms to define precise data elements. CDISC ODM and SDM standards are extended using an archetype approach to enable a two-level model of individual data elements, representing both research content and clinical content. Separate configurations of the TRANSFoRm tools serve each use case. Conclusions. The project has been successful in using ontologies and archetypes to develop a highly flexible solution to the problem of heterogeneity of data sources presented by the LHS.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine | ||||||||
| Divisions: | Faculty of Science > WMG (Formerly the Warwick Manufacturing Group) | ||||||||
| Library of Congress Subject Headings (LCSH): | Evidence-based medicine, Medical informatics, Medical care -- Research | ||||||||
| Journal or Publication Title: | BioMed Research International | ||||||||
| Publisher: | Hindawi Publishing Corporation | ||||||||
| ISSN: | 2314-6133 | ||||||||
| Official Date: | 2015 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 5 February 2016 | ||||||||
| Volume: | 2015 | ||||||||
| Number of Pages: | 8 | ||||||||
| DOI: | 10.1155/2015/961526 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | Seventh Framework Programme (European Commission) (FP7), National Institute for Health Research (Great Britain) (NIHR), Guy's & St. Thomas' NHS Foundation Trust | ||||||||
| Grant number: | 247787 (FP7) |
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