Cloning and characterisation of the immunophilin X-CypA in Xenopus laevis
UNSPECIFIED. (2004) Cloning and characterisation of the immunophilin X-CypA in Xenopus laevis. GENE EXPRESSION PATTERNS, 5 (1). pp. 51-60. ISSN 1567-133XFull text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.modgep.2004.06.007
This paper reports the cloning of Xenopus laevis, cyclophilin A gene, X-CypA. This study is the first developmental and functional characterisation in vivo of cyclophilin A in a vertebrate. X-CypA belongs to the superfamily of the immunophilin/PPIase proteins that can bind the immunosuppressant drug Cyclosporin A. Sequence analysis showed that X-CypA is highly conserved during evolution. RT-PCR and in situ hybridisation analysis showed that X-CypA expression is regulated during development and its transcripts are found in three major expression domains: nervous system, sensory organs and pronephros. Over-expression of X-CypA in embryos, analysed by in situ hybridisation and RT-PCR, leads to an expansion and disorganisation of the neural crest domain. (C) 2004 Elsevier B.V. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
|Journal or Publication Title:||GENE EXPRESSION PATTERNS|
|Publisher:||ELSEVIER SCIENCE BV|
|Number of Pages:||10|
|Page Range:||pp. 51-60|
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