Carhan, Ahmet, Reeve, Simon, Dee, Chris T., Baines, Richard A. and Moffat, Kevin G. (2004) Mutation in slowmo causes defects in Drosophila larval locomotor behaviour. INVERTEBRATE NEUROSCIENCE, 5 (2). pp. 65-75. doi:10.1007/s10158-003-0028-y ISSN 1354-2516.

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Abstract

We have identified a mutant slowmotion phenotype in first instar larval peristaltic behaviour of Drosophila. By the end of embryogenesis and during early first instar phases, slowmo mutant animals show a marked decrease in locomotory behaviour, resulting from both a reduction in number and rate of peristaltic contractions. Inhibition of neurotransmitter release, using targeted expression of tetanus toxin light chain (TeTxLC), in the slowmo neurons marked by an enhancer-trap results in a similar phenotype of largely absent or uncoordinated contractions. Cloning of the slowmo gene identifies a product related to a family of proteins of unknown function. We show that Slowmo is associated with mitochondria, indicative of it being a mitochondrial protein, and that during embryogenesis and early larval development is restricted to the nervous system in a subset of cells. The enhancer-trap marks a cellular component of the CNS that is seemingly required to regulate peristaltic movement.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Journal or Publication Title:	INVERTEBRATE NEUROSCIENCE
Publisher:	SPRINGER HEIDELBERG
ISSN:	1354-2516
Official Date:	October 2004
Dates:	Date Event October 2004 UNSPECIFIED
Volume:	5
Number:	2
Number of Pages:	11
Page Range:	pp. 65-75
DOI:	10.1007/s10158-003-0028-y
Publication Status:	Published

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