Mutation in slowmo causes defects in Drosophila larval locomotor behaviour
Carhan, Ahmet, Reeve, Simon, Dee, Chris T., Baines, Richard A. and Moffat, Kevin G.. (2004) Mutation in slowmo causes defects in Drosophila larval locomotor behaviour. INVERTEBRATE NEUROSCIENCE, 5 (2). pp. 65-75. ISSN 1354-2516Full text not available from this repository.
Official URL: http://dx.doi.org/10.1007/s10158-003-0028-y
We have identified a mutant slowmotion phenotype in first instar larval peristaltic behaviour of Drosophila. By the end of embryogenesis and during early first instar phases, slowmo mutant animals show a marked decrease in locomotory behaviour, resulting from both a reduction in number and rate of peristaltic contractions. Inhibition of neurotransmitter release, using targeted expression of tetanus toxin light chain (TeTxLC), in the slowmo neurons marked by an enhancer-trap results in a similar phenotype of largely absent or uncoordinated contractions. Cloning of the slowmo gene identifies a product related to a family of proteins of unknown function. We show that Slowmo is associated with mitochondria, indicative of it being a mitochondrial protein, and that during embryogenesis and early larval development is restricted to the nervous system in a subset of cells. The enhancer-trap marks a cellular component of the CNS that is seemingly required to regulate peristaltic movement.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
|Journal or Publication Title:||INVERTEBRATE NEUROSCIENCE|
|Number of Pages:||11|
|Page Range:||pp. 65-75|
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