UNSPECIFIED (2003) Compartmental modelling to assess stability of topotecan bound to DNA. In: 5th IFAC Symposium on Modelling and Control in Biomedical Systems, AUG 21-23, 2003, MELBOURNE, AUSTRALIA.

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Abstract

In this paper, a compartmental model is proposed for describing the in vitro kinetics of the anti-cancer agent topotecan following administration into a culture medium containing human lymphoma cells in suspension. The model extends one previously proposed by including an extra dissociation pathway, with the objective of describing the effect of DNA binding on the stability of bound topotecan. The structural identifiability and steady states of the model are analysed. The model is fitted to high performance liquid chromatography data and it is found that there is a qualitative difference between the predicted behaviour of the new model and that of the previous model. Copyright (C) 2003 IFAC.

Item Type:	Conference Item (UNSPECIFIED)
Subjects:	Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software R Medicine T Technology > TK Electrical engineering. Electronics Nuclear engineering
Series Name:	IFAC SYMPOSIA SERIES
Journal or Publication Title:	MODELLING AND CONTROL IN BIOMEDICAL SYSTEMS 2003 (INCLUDING BIOLOGICAL SYSTEMS)
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
ISBN:	0-08-044159-9
ISSN:	0962-9505
Editor:	Feng, D and Carson, ER
Date:	2003
Number of Pages:	6
Page Range:	pp. 403-408
Publication Status:	Published
Title of Event:	5th IFAC Symposium on Modelling and Control in Biomedical Systems
Location of Event:	MELBOURNE, AUSTRALIA
Date(s) of Event:	AUG 21-23, 2003
URI:	http://wrap.warwick.ac.uk/id/eprint/7670

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