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Is there a familial association between obstructive sleep apnoea/hypopnoea and the sudden infant death syndrome?
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Vennelle, M., Brander, P. E., Kingshott, R. N. , Rees, Karen, Warren, P. M., Keeling, J. W. and Douglas, N. J. (2004) Is there a familial association between obstructive sleep apnoea/hypopnoea and the sudden infant death syndrome? Thorax, 59 (4). pp. 337-341. doi:10.1136/thx.2003.006783 ISSN 0040-6376.
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Official URL: http://dx.doi.org/10.1136/thx.2003.006783
Abstract
Background: One postulated cause of the sudden infant death syndrome (SIDS) is upper airway obstruction during sleep. Several studies have suggested that SIDS may be more common in families with obstructive sleep apnoea/hypopnoea syndrome (OSAHS), but were limited by uncertainty as to whether the deaths were due to SIDS. We have tested the hypothesis that parents of true SIDS cases have an increased frequency of apnoeas and hypopnoeas during sleep.
Methods: The parents of 269 rigorously determined SIDS cases were invited for single night polysomnography and daytime ventilatory control measurement.
Results: Parents of 198 cases were identified but 152 did not respond or declined. Fifty five parents of 34 cases were studied and matched for age, height, and weight to 55 subjects from general practice registers. There was no difference in breathing during sleep between the parents of SIDS cases (median (IQR) 5.9 (3.2, 10.7) apnoeas+hypopnoeas/h) and controls (6.7 (4.0, 12.2) apnoeas+hypopnoeas/h; p = 0.47), but the SIDS parents had lower minimum nocturnal oxygen saturation (median (IQR) 92 (89, 93)%) than controls (92 (90, 94)%; p = 0.048). There were no major differences in control of breathing when awake between SIDS parents and controls.
Conclusions: These results provide no evidence to support an association between SIDS and OSAHS. However, the minor impairment of oxygenation during sleep in SIDS parents requires further study.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Thorax | ||||
Publisher: | BMJ | ||||
ISSN: | 0040-6376 | ||||
Official Date: | 2004 | ||||
Dates: |
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Volume: | 59 | ||||
Number: | 4 | ||||
Page Range: | pp. 337-341 | ||||
DOI: | 10.1136/thx.2003.006783 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) |
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