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Activation of ice recrystallization inhibition activity of poly(vinyl alcohol) using a supramolecular trigger
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Phillips, Daniel J., Congdon, Thomas R. and Gibson, Matthew I. (2016) Activation of ice recrystallization inhibition activity of poly(vinyl alcohol) using a supramolecular trigger. Polymer Chemistry, 7 . pp. 1701-1704. doi:10.1039/c5py01948f
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Official URL: http://dx.doi.org/10.1039/C5PY01948F
Abstract
Antifreeze (glyco)proteins (AF(G)Ps) have potent ice recrystallisation inhibition (IRI) activity – a desirable phenomenon in applications such as cryopreservation, frozen food and more. In Nature AF(G)P activity is regulated by protein expression levels in response to an environmental stimulus; temperature. However, this level of regulation is not possible in synthetic systems. Here, a synthetic macromolecular mimic is introduced, using supramolecular assembly to regulate activity. Catechol-terminated poly(vinyl alcohol) was synthesised by RAFT polymerization. Upon addition of Fe3+, larger supramolecular star polymers form by assembly with two or three catechols. This increase in molecular weight effectively ‘switches on’ the IRI activity and is the first example of external control over the function of AFP mimetics. This provides a simple but elegant solution to the challenge of external control of AFP-mimetic function.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QC Physics Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science > Chemistry Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Antifreeze proteins, Crystallization, Ice crystals -- Growth, Cryobiology, Polymers, Macromolecules | ||||||||
| Journal or Publication Title: | Polymer Chemistry | ||||||||
| Publisher: | Royal Society of Chemistry | ||||||||
| ISSN: | 1759-9954 | ||||||||
| Official Date: | 29 January 2016 | ||||||||
| Dates: |
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| Volume: | 7 | ||||||||
| Page Range: | pp. 1701-1704 | ||||||||
| DOI: | 10.1039/c5py01948f | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Funder: | Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Leverhulme Trust (LT), European Research Council (ERC) | ||||||||
| Grant number: | RPG-144, CRYOMAT 638661 |
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