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Activation of ice recrystallization inhibition activity of poly(vinyl alcohol) using a supramolecular trigger

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Phillips, Daniel J., Congdon, Thomas R. and Gibson, Matthew I. (2016) Activation of ice recrystallization inhibition activity of poly(vinyl alcohol) using a supramolecular trigger. Polymer Chemistry, 7 . pp. 1701-1704. doi:10.1039/c5py01948f ISSN 1759-9954.

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Official URL: http://dx.doi.org/10.1039/C5PY01948F

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Abstract

Antifreeze (glyco)proteins (AF(G)Ps) have potent ice recrystallisation inhibition (IRI) activity – a desirable phenomenon in applications such as cryopreservation, frozen food and more. In Nature AF(G)P activity is regulated by protein expression levels in response to an environmental stimulus; temperature. However, this level of regulation is not possible in synthetic systems. Here, a synthetic macromolecular mimic is introduced, using supramolecular assembly to regulate activity. Catechol-terminated poly(vinyl alcohol) was synthesised by RAFT polymerization. Upon addition of Fe3+, larger supramolecular star polymers form by assembly with two or three catechols. This increase in molecular weight effectively ‘switches on’ the IRI activity and is the first example of external control over the function of AFP mimetics. This provides a simple but elegant solution to the challenge of external control of AFP-mimetic function.

Item Type: Journal Article
Subjects: Q Science > QC Physics
Q Science > QD Chemistry
Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Antifreeze proteins, Crystallization, Ice crystals -- Growth, Cryobiology, Polymers, Macromolecules
Journal or Publication Title: Polymer Chemistry
Publisher: Royal Society of Chemistry
ISSN: 1759-9954
Official Date: 29 January 2016
Dates:
DateEvent
29 January 2016Available
28 January 2016Accepted
7 December 2015Submitted
Volume: 7
Page Range: pp. 1701-1704
DOI: 10.1039/c5py01948f
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 11 February 2016
Date of first compliant Open Access: 12 February 2016
Funder: Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Leverhulme Trust (LT), European Research Council (ERC)
Grant number: RPG-144, CRYOMAT 638661

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