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Genetically modified bacteriophages
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Sagona, Antonia P., Grigonyte, Aurelija M., MacDonald, Paul and Jaramillo, Alfonso (2016) Genetically modified bacteriophages. Integrative Biology, 8 . pp. 465-474. doi:10.1039/c5ib00267b ISSN 1757-9694.
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Official URL: http://dx.doi.org/10.1039/C5IB00267B
Abstract
Phages or bacteriophages, viruses that infect and replicate inside bacteria, are the most abundant microorganisms on earth. The realization that antibiotic resistance poses a substantial risk to the world’s health and global economy is revitalizing phage therapy as a potential solution. The increasing ease by which phage genomes can be modified, owing to the influx of new technologies, has led to an expansion of their natural capabilities, and a reduced dependence on phage isolation from environmental sources. This review will discuss the way synthetic biology has accelerated the construction of genetically modified phages and will describe the wide range of their applications. It will further provide insight into the societal and economic benefits that derive from the use of recombinant phages in various sectors, from health to biodetection, biocontrol and the food industry.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QR Microbiology | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||
Library of Congress Subject Headings (LCSH): | Bacteriophages -- Genetic engineering | ||||||||||
Journal or Publication Title: | Integrative Biology | ||||||||||
Publisher: | Royal Society of Chemistry | ||||||||||
ISSN: | 1757-9694 | ||||||||||
Official Date: | 1 April 2016 | ||||||||||
Dates: |
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Volume: | 8 | ||||||||||
Page Range: | pp. 465-474 | ||||||||||
DOI: | 10.1039/c5ib00267b | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 19 February 2016 | ||||||||||
Date of first compliant Open Access: | 16 August 2016 | ||||||||||
Funder: | Seventh Framework Programme (European Commission) (FP7), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC) | ||||||||||
Grant number: | 610730 (FP7), BB/M017982/1 (BBSRC), EP/F500378/1 (EPSRC), EP/L016494/1 (EPSRC) |
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