The Library
Microbial diversity arising from thermodynamic constraints
Tools
Großkopf, Tobias and Soyer, Orkun S. (2016) Microbial diversity arising from thermodynamic constraints. The ISME Journal, 10 . pp. 2725-2733. doi:10.1038/ismej.2016.49 ISSN 1751-7362.
|
PDF
WRAP_ismej201649a.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1121Kb) | Preview |
|
PDF
WRAP_9414_1_merged_1455807300.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (591Kb) |
Official URL: http://dx.doi.org/10.1038/ismej.2016.49
Abstract
The microbial world displays an immense taxonomic diversity. This diversity is manifested also in a multitude of metabolic pathways that can utilize different substrates and produce different products. Here, we propose that these observations directly link to thermodynamic constraints that inherently arise from the metabolic basis of microbial growth. We show that thermodynamic constraints can enable coexistence of microbes that utilise the same substrate but produce different end products. We find that this thermodynamics-driven emergence of diversity is most relevant for metabolic conversions with low free energy as seen for example under anaerobic conditions, where population dynamics is governed by thermodynamic effects rather than kinetic factors such as substrate uptake rates. These findings provide a general understanding of the microbial diversity based on the first-principles of thermodynamics. As such they provide a thermodynamics-based framework for explaining the observed microbial diversity in different natural and synthetic environments.
Item Type: | Journal Article | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QC Physics Q Science > QR Microbiology |
||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||
Library of Congress Subject Headings (LCSH): | Microbial diversity, Thermodynamics, Microbial growth | ||||||||||
Journal or Publication Title: | The ISME Journal | ||||||||||
Publisher: | Nature Publishing Group | ||||||||||
ISSN: | 1751-7362 | ||||||||||
Official Date: | November 2016 | ||||||||||
Dates: |
|
||||||||||
Volume: | 10 | ||||||||||
Page Range: | pp. 2725-2733 | ||||||||||
DOI: | 10.1038/ismej.2016.49 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 2 March 2016 | ||||||||||
Date of first compliant Open Access: | 23 June 2016 | ||||||||||
Funder: | Isaac Newton Institute for Mathematical Sciences, Wissenschaft Kollege zu Berlin (WIKO), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||||||||
Grant number: | BB/K003240/2 (BBSRC) |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year