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People of the British Isles : preliminary analysis of genotypes and surnames in a UK control population
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(2012) People of the British Isles : preliminary analysis of genotypes and surnames in a UK control population. European Journal of Human Genetics, 20 . pp. 203-210. doi:10.1038/ejhg.2011.127 ISSN 1018-4813.
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Official URL: http://doi.org/10.1038/ejhg.2011.127
Abstract
There is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to have a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. In this study, we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK-control population that can be used as a resource by the research community, as well as providing a fine-scale genetic information on the British population. So far, some 4000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3 km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1057 samples demonstrates the value of these samples for investigating a fine-scale population structure within the UK, and shows how this can be enhanced by the use of surnames.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | European Journal of Human Genetics | ||||||
Publisher: | Nature Publishing Group | ||||||
ISSN: | 1018-4813 | ||||||
Official Date: | 10 August 2012 | ||||||
Dates: |
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Volume: | 20 | ||||||
Page Range: | pp. 203-210 | ||||||
DOI: | 10.1038/ejhg.2011.127 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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