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Slip slidin' away : a duodecennial review of targeted genes in mismatch repair deficient colorectal cancer
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Royrvik, E. C., Ahlquist, T., Rognes, T. and Lothe, R. A. (2007) Slip slidin' away : a duodecennial review of targeted genes in mismatch repair deficient colorectal cancer. Critical Reviews in Oncogenesis, 13 (3). pp. 229-257. doi:10.1615/CritRevOncog.v13.i3.20
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Official URL: http://doi.org/10.1615/CritRevOncog.v13.i3.20
Abstract
Roughly 15% of colorectal tumors are characterized by microsatellite instability (MSI), a deficiency caused by defective DNA mismatch repair, which leads to profuse insertions and deletions in microsatellites. Downstream target genes of this defective repair are those prone to exhibit these insertion/deletion mutations in their coding regions and potentially having functional consequences in, and providing a growth advantage for, the cancer cell. This review presents the last 12 years of research on these MSI target genes, systematizing the mutation details of the more than 160 genes identified to date, and includes their mutation frequencies in colorectal and other MSI (e.g., gastric and endometrial) tumors. Functional aspects of certain targets and the target gene concept itself are also discussed, as is the comparative wealth of potential target genes assessed by scanning the coding sequences of the human genome for mononucleotide repeats--yet to be investigated.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Critical Reviews in Oncogenesis | ||||||
| Publisher: | Begell House, Inc. | ||||||
| ISSN: | 0893-9675 | ||||||
| Official Date: | 2007 | ||||||
| Dates: |
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| Volume: | 13 | ||||||
| Number: | 3 | ||||||
| Page Range: | pp. 229-257 | ||||||
| DOI: | 10.1615/CritRevOncog.v13.i3.20 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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