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Antecedents of attention-deficit/hyperactivity disorder symptoms in children born extremely preterm
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Johnson, Samantha J., Kochhar, Puja, Hennessy, E., Marlow, Neil, Wolke, Dieter and Hollis, Chris (2016) Antecedents of attention-deficit/hyperactivity disorder symptoms in children born extremely preterm. Journal of Developmental and Behavioral Pediatrics, 37 (4). pp. 285-297. doi:10.1097/DBP.0000000000000298 ISSN 0196-206X.
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WRAP_0671038-ps-010316-johnson_et_al_2015_epicure_adhd_jdbp_2nd_revision_final %281%29.pdf - Accepted Version - Requires a PDF viewer. Download (849Kb) | Preview |
Official URL: http://dx.doi.org/10.1097/DBP.0000000000000298
Abstract
Objective. To investigate antecedents of Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms in children born extremely preterm (EP; <26 weeks gestation).
Method. The EPICure Study recruited all babies born EP in the UK and Ireland in March-December 1995. Neurodevelopmental outcomes were assessed at 2.5 (n=283; 90%), 6 (n=160; 78%) and 11 (n=219; 71%) years of age. Parents and teachers completed the Du Paul Rating Scale-IV to assess inattention and hyperactivity/impulsivity symptoms at 11 years. Regression analyses were used to explore the association of neonatal, neurodevelopmental and behavioral outcomes to 6 years with ADHD symptoms at 11 years.
Results. EP children had significantly more inattention (mean difference 1.2 SD; 95% CI 0.9, 1.5) and hyperactivity/impulsivity (0.5 SD; 0.2, 0.7) than controls, with a significantly greater effect size for inattention than hyperactivity/impulsivity. Significant independent predictors of inattention at 11 years included smaller head circumference, lower IQ and pervasive peer relationship problems at 6 years, and motor development at 2.5 years. In contrast, significant independent predictors of hyperactivity/impulsivity included lower IQ, pervasive conduct problems and ADHD symptoms at 6 years, externalizing problems at 2.5 years and non-white maternal ethnicity.
Conclusions. EP children are at increased risk for ADHD symptoms, predominantly inattention, for which the antecedents differ by symptom domain. Attention deficits following EP birth were associated with poor brain growth and neurological function. Cognitive and behavioral assessments in early and middle childhood to identify neurodevelopmental and peer relationship problems may be beneficial for identifying EP children at risk for inattention.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Journal of Developmental and Behavioral Pediatrics | ||||||
Publisher: | Lippincott Williams & Wilkins | ||||||
ISSN: | 0196-206X | ||||||
Official Date: | May 2016 | ||||||
Dates: |
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Volume: | 37 | ||||||
Number: | 4 | ||||||
Page Range: | pp. 285-297 | ||||||
DOI: | 10.1097/DBP.0000000000000298 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||
Date of first compliant deposit: | 9 March 2016 | ||||||
Date of first compliant Open Access: | 1 June 2017 | ||||||
Adapted As: | 10.1097/DBP.0000000000000298 |
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