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Preparation of orthogonally-functionalized core Click cross-linked nanoparticles
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O’Reilly, Rachel K., Joralemon, Maisie J., Hawker, Craig J. and Wooley, Karen L. (2007) Preparation of orthogonally-functionalized core Click cross-linked nanoparticles. New Journal of Chemistry, 31 (5). pp. 718-724. doi:10.1039/b616103k ISSN 1144-0546.
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Official URL: http://dx.doi.org/10.1039/B616103K
Abstract
The preparation of well-defined core cross-linked polymeric nanoparticles is reported, utilizing multi-functional dendritic cross-linkers that allow for the effective stabilization of supramolecular polymer assemblies and the simultaneous introduction of reactive groups within the core domain. Amphiphilic diblock copolymers of poly(acrylic acid)-b-poly(styrene) (PAA-b-PS) that contained alkynyl functionality, partially incorporated throughout the hydrophobic PS block segment, were utilized as Click-readied precursors for the formation of polymer micelles. Divergently-grown dendrimers of the zero, first, second and third generations, having increasing numbers of azide terminating groups ((N3)2-[G-0], (N3)4-[G-1], (N3)8-[G-2], and (N3)16-[G-3], respectively), were investigated as cross-linkers via Click reactions with the polymer alkynyl groups to form covalent linkages throughout the micellar core domains, thus forming core cross-linked nanoparticles. All four generations of dendrimers were found to cross-link the micelle core effectively and afford robust nanostructures, whilst simultaneously introducing Click-readied functionalities throughout the hydrophobic domain, which are proposed to be readily available for further chemical modification.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | New Journal of Chemistry | ||||
Publisher: | Royal Society of Chemistry | ||||
ISSN: | 1144-0546 | ||||
Official Date: | 2007 | ||||
Dates: |
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Volume: | 31 | ||||
Number: | 5 | ||||
Page Range: | pp. 718-724 | ||||
DOI: | 10.1039/b616103k | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published |
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