UNSPECIFIED (2004) New roles for FoxH1 in patterning the early embryo. DEVELOPMENT, 131 (20). pp. 5065-5078. ISSN 0950-1991

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Abstract

FoxH1 (Fast1) was first characterized as the transcriptional partner for Smad proteins. Together with Smad2/4, it forms the activin response factor (ARF) that binds to the Mix.2 promoter in Xenopus embryos. Foxh1 is expressed maternally in Xenopus. Depletion of maternal Foxh1 mRNA results in abnormalities of head and dorsal axis formation. We show that FoxH1 is required, together with XTcf3/beta catenin, to activate the zygotic expression of the nodal gene, Xnr3 in a Smad2-independent manner. In contrast, maternal FoxH1 acts as an inhibitor of Xnr5 and 6 transcription, preventing their upregulation on the ventral side of the embryo, by the maternal T-box transcription factor VegT. We conclude that maternal FoxH1 has essential, context-dependent roles in regulating the pattern of zygotic gene expression in the early embryo.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Journal or Publication Title:	DEVELOPMENT
Publisher:	COMPANY OF BIOLOGISTS LTD
ISSN:	0950-1991
Date:	October 2004
Volume:	131
Number:	20
Number of Pages:	14
Page Range:	pp. 5065-5078
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/7785

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