Enquselassie, F., Ayele, W., Dejene, A., Messele, T., Abebe, A., Cutts, Felicity and Nokes, D. James (2003) Seroepidemiology of measles in Addis Ababa Ethiopia: implications for control through vaccination. Epidemiology and Infection, Vol.13 (No.3). pp. 507-519. doi:10.1017/S0950268803008446

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Abstract

We undertook a representative survey of measles antibodies in Addis Ababa, Ethiopia 1994, to characterize immunity and transmission. Specific-antibody levels (IU/l) were determined by ELISA for 4654 sera from individuals aged 0–49 years (1805 <15 years) collected by stratified household-cluster sampling. The proportion seronegative (<100 IU/l) was 20% (95% CI : 16–25) in children 9–59 months old, declining to 9% (7–12) in 5–9 year olds, 5% (4–7) in 10–14 year olds, and <1% in adults. The proportion of children (<15 years old) with low-level antibody (100–255 IU/l) was 8% (7–10). Vaccination and an absence of a history of measles illness were strongly associated with low-level antibody. History of measles vaccination in 9 months to 14-year-old children was y80%. We estimate a primary vaccine failure rate of 21% (12–34) and continued high measles incidence of 22 per 100 susceptibles (19–24) per annum. Our data support the introduction of campaign vaccination in the city in 1998, although higher routine vaccine coverage is required to sustain the impact. The implications of a high prevalence of low-level antibody are discussed.

Item Type:	Journal Article
Subjects:	R Medicine > RB Pathology R Medicine > RA Public aspects of medicine
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Library of Congress Subject Headings (LCSH):	Measles -- Ethiopia, Epidemiology -- Research -- Ethiopia, Measles -- Vaccination -- Ethiopia, Public health -- Research -- Ethiopia, Addis Ababa (Ethiopia) -- Social conditions
Journal or Publication Title:	Epidemiology and Infection
Publisher:	Cambridge University Press
ISSN:	0950-2688
Official Date:	June 2003
Dates:	Date Event June 2003 Published
Volume:	Vol.13
Number:	No.3
Page Range:	pp. 507-519
DOI:	10.1017/S0950268803008446
Status:	Peer Reviewed
Access rights to Published version:	Open Access
Funder:	Royal Society (Great Britain), Wellcome Trust (London, England)
Grant number:	039056 (Wellcome)

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