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Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol–ene radical reactions
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Sun, Liang, Pitto-Barry, Anaïs, Thomas, Anthony W., Inam, Maria, Doncom, Kay E. B., Dove, Andrew P. and O'Reilly, Rachel K. (2016) Core functionalization of semi-crystalline polymeric cylindrical nanoparticles using photo-initiated thiol–ene radical reactions. Polymer Chemistry, 7 (13). pp. 2337-2341. doi:10.1039/c5py01970b ISSN 1759-9954.
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Official URL: http://dx.doi.org/10.1039/C5PY01970B
Abstract
Sequential ring-opening and reversible addition–fragmentation chain transfer (RAFT) polymerization was used to form a triblock copolymer of tetrahydropyran acrylate (THPA), 5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one (MAC) and L-lactide. Concurrent deprotection of the THPA block and crystallization-driven self-assembly (CDSA) was undertaken and allowed for the formation of cylindrical micelles bearing allyl handles in a short outer core segment. These handles were further functionalized by different thiols using photo-initiated thiol–ene radical reactions to demonstrate that the incorporation of an amorphous PMAC block within the core does not disrupt CDSA and can be used to load the cylindrical nanoparticles with cargo.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
Library of Congress Subject Headings (LCSH): | Nanoparticles | ||||||||||
Journal or Publication Title: | Polymer Chemistry | ||||||||||
Publisher: | Royal Society of Chemistry | ||||||||||
ISSN: | 1759-9954 | ||||||||||
Official Date: | 7 April 2016 | ||||||||||
Dates: |
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Volume: | 7 | ||||||||||
Number: | 13 | ||||||||||
Page Range: | pp. 2337-2341 | ||||||||||
DOI: | 10.1039/c5py01970b | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 8 July 2016 | ||||||||||
Date of first compliant Open Access: | 8 July 2016 | ||||||||||
Funder: | Royal Society (Great Britain), Engineering and Physical Sciences Research Council (EPSRC), European Research Council (ERC) |
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