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Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage <phi>X174 lysis protein E, and cationic antibacterial peptides
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Bugg, Tim, Rodolis, Maria T., Mihalyi, Agnes and Jamshidi, Shirin (2016) Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage <phi>X174 lysis protein E, and cationic antibacterial peptides. Bioorganic and Medicinal Chemistry . doi:10.1016/j.bmc.2016.03.018 ISSN 0968-0896.
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WRAP_9970029-ch-110316-mray_review_2016_v2_unmarked.pdf - Accepted Version - Requires a PDF viewer. Download (1372Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.bmc.2016.03.018
Abstract
This review covers recent developments in the inhibition of translocase MraY and related phospho-GlcNAc transferases WecA and TagO, and insight into the inhibition and catalytic mechanism of this class of integral membrane proteins from the structure of Aquifex aeolicus MraY. Recent studies have also identified a protein-protein interaction site in E. coli MraY, that is targeted by bacteriophage X174 lysis protein E, and also by cationic antimicrobial peptides containing Arg-Trp close to their N- or C-termini.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QP Physiology Q Science > QR Microbiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Library of Congress Subject Headings (LCSH): | Bacteria -- Polysaccharide content , Peptidoglycans, Eubacteriales, Endotoxins , Enzymology, Enzymes | ||||||||
Journal or Publication Title: | Bioorganic and Medicinal Chemistry | ||||||||
Publisher: | Pergamon Press | ||||||||
ISSN: | 0968-0896 | ||||||||
Official Date: | 9 March 2016 | ||||||||
Dates: |
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Number of Pages: | 20 | ||||||||
DOI: | 10.1016/j.bmc.2016.03.018 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 23 March 2016 | ||||||||
Date of first compliant Open Access: | 9 March 2017 | ||||||||
Funder: | National Science Foundation (U.S.) (NSF), Medical Research Council (Great Britain) (MRC), University of Warwick | ||||||||
Grant number: | G1100127 (MRC) | ||||||||
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