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Stability of small ubiquitin-like modifier (SUMO) proteases OVERLY TOLERANT TO SALT1 and -2 modulates salicylic acid signalling and SUMO1/2 conjugation in Arabidopsis thaliana
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Bailey, Mark, Srivastava, Anjil, Conti, Lucio, Nelis, Stuart, Zhang, Cunjin, Florance, Hannah, Love, Andrew, Milner, Joel, Napier, R. (Richard), Grant, Murray R. and Sadanandom, Ari (2016) Stability of small ubiquitin-like modifier (SUMO) proteases OVERLY TOLERANT TO SALT1 and -2 modulates salicylic acid signalling and SUMO1/2 conjugation in Arabidopsis thaliana. Journal of Experimental Botany, 67 (1). pp. 353-363. doi:10.1093/jxb/erv468 ISSN 0022-0957.
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Official URL: http://dx.doi.org/10.1093/jxb/erv468
Abstract
Small ubiquitin-like modifier proteases 1 and 2 (SUMO1/2) have been linked to the regulation of salicylic acid (SA)-mediated defence signalling in Arabidopsis thaliana. In order to define the role of the SUMO proteases OVERLY TOLERANT TO SALT1 and -2 (OTS1/2) in defence and to provide insight into SUMO1/2-mediated regulation of SA signalling, we examined the status of SA-mediated defences in ots1/2 mutants. The ots1 ots2 double mutant displayed enhanced resistance to virulent Pseudomonas syringae and higher levels of SA compared with wild-type (WT) plants. Furthermore, ots1 ots2 mutants exhibited upregulated expression of the SA biosynthesis gene ICS1 in addition to enhanced SA-responsive ICS1 expression beyond that of WT. SA stimulated OTS1/2 degradation and promoted accumulation of SUMO1/2 conjugates. These results indicate that OTS1 and -2 act in a feedback loop in SA signalling and that de novo OTS1/2 synthesis works antagonistically to SA-promoted degradation, adjusting the abundance of OTS1/2 to moderate SA signalling. Accumulation of SUMO1/2 conjugates coincides with SA-promoted OTS degradation and may play a positive role in SA-mediated signalling in addition to its repressive roles reported elsewhere.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QK Botany | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Arabidopsis thaliana, Plant-pathogen relationships, Salicylic acid | ||||||||
| Journal or Publication Title: | Journal of Experimental Botany | ||||||||
| Publisher: | Oxford University Press | ||||||||
| ISSN: | 0022-0957 | ||||||||
| Official Date: | 2016 | ||||||||
| Dates: |
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| Volume: | 67 | ||||||||
| Number: | 1 | ||||||||
| Number of Pages: | 11 | ||||||||
| Page Range: | pp. 353-363 | ||||||||
| DOI: | 10.1093/jxb/erv468 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 23 March 2016 | ||||||||
| Date of first compliant Open Access: | 24 March 2016 | ||||||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), European Research Council (ERC) | ||||||||
| Grant number: | BB/D017319 (BBSRC) |
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