Studies toward the synthesis of luminacin D: Assembly of simplified analogues devoid of the epoxide displaying antiangiogenic activity
UNSPECIFIED. (2004) Studies toward the synthesis of luminacin D: Assembly of simplified analogues devoid of the epoxide displaying antiangiogenic activity. ORGANIC LETTERS, 6 (22). pp. 3909-3912. ISSN 1523-7060Full text not available from this repository.
Official URL: http://dx.doi.org/10.1021/ol048462v
[GRAPHICS] A series of structurally simplified luminacin analogues devoid of the epoxide ring are assembled in a stereocontrolled manner from 2,4-dimethoxybenzaldehyde using a syn-selective aldol reaction as the key step. The success of the approach is critically dependent on the nature and extent of the alcohol protecting groups. The synthetic analogues inhibit VEGF-stimulated angiogenesis in an in vitro assay indicating that the epoxide is not essential for biological activity in this compound class.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Journal or Publication Title:||ORGANIC LETTERS|
|Publisher:||AMER CHEMICAL SOC|
|Date:||28 October 2004|
|Number of Pages:||4|
|Page Range:||pp. 3909-3912|
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