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Controlled Aassembly of artificial protein–protein complexes via DNA duplex formation
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Płoskoń, Eliza, Wagner, Sara C., Ellington, Andrew, Jewett, Michael, O’Reilly, Rachel K. and Booth, Paula J. (2015) Controlled Aassembly of artificial protein–protein complexes via DNA duplex formation. Bioconjugate Chemistry, 26 (3). pp. 427-434. doi:10.1021/bc500473s ISSN 1043-1802.
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Official URL: http://dx.doi.org/10.1021/bc500473s
Abstract
DNA–protein conjugates have found a wide range of applications. This study demonstrates the formation of defined, non-native protein–protein complexes via the site specific labeling of two proteins of interest with complementary strands of single-stranded DNA in vitro. This study demonstrates that the affinity of two DNA–protein conjugates for one another may be tuned by the use of variable lengths of DNA allowing reversible control of complex formation.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||
Journal or Publication Title: | Bioconjugate Chemistry | ||||||
Publisher: | American Chemical Society | ||||||
ISSN: | 1043-1802 | ||||||
Official Date: | 20 January 2015 | ||||||
Dates: |
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Volume: | 26 | ||||||
Number: | 3 | ||||||
Page Range: | pp. 427-434 | ||||||
DOI: | 10.1021/bc500473s | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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